SCHEMBL28898

SCHEMBL28898

[S]Cc1cccc2ccccc12

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 3/20 0.58
CYP2C19 P33261 2/20 0.58
CYP2C9 P11712 1/20 0.58
TDP1 Q9NUW8 2/20 0.57
CYP2D6 P10635 3/20 0.54
ACP3 P15309 1/20 0.50
ALDH1A1 P00352 2/20 0.47
KDM4E B2RXH2 1/20 0.47
GAA P10253 1/20 0.47
HPGD P15428 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
ADRA2A P08913 4/20 0.47
ADRA2B P18089 4/20 0.47
ADRA2C P18825 4/20 0.47
ADRA1A P35348 3/20 0.47
ADRA1D P25100 2/20 0.47
ADRA1B P35368 2/20 0.47
LMNA P02545 1/20 0.46
HTR1A P08908 1/20 0.46
MAPT P10636 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL131469 0.87 HPRT1 (0.58) CYP1A2CYP2C19CYP2C9TDP1CYP2D6
SCHEMBL29490353 0.84 CYP2C19 (0.62) CYP1A2CYP2C19CYP2C9TDP1CYP2D6
SCHEMBL599659 0.84 CYP2C19 (0.62) CYP1A2CYP2C19CYP2C9TDP1CYP2D6
SCHEMBL659516 0.82 CYP2C19 (0.60) CYP1A2CYP2C19CYP2C9TDP1CYP2D6
SCHEMBL659517 0.82 CYP2C19 (0.60) CYP1A2CYP2C19CYP2C9TDP1CYP2D6
SCHEMBL11339937 0.82 CYP2C19 (0.60) CYP1A2CYP2C19CYP2C9TDP1CYP2D6
SCHEMBL11328087 0.82 CYP2C19 (0.60) CYP1A2CYP2C19CYP2C9TDP1CYP2D6
Hydrogen Sulfide SCHEMBL11348128 0.82 CYP2C19 (0.60) CYP1A2CYP2C19CYP2C9TDP1CYP2D6
SCHEMBL4667060 0.82 CYP2C19 (0.60) CYP1A2CYP2C19CYP2C9TDP1CYP2D6
Potassium SCHEMBL29867531 0.82 CYP2C19 (0.60) CYP1A2CYP2C19CYP2C9TDP1CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 658 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2008127275-A2 PYRROLINONE COMPOUNDS AS INHIBITORS OF BACTERIAL PEPTIDYL TRNA HYDROLASE AND USES THEREOF PTC THERAPEUTICS, INC. (US) 2008-10-23 WO claimed
EP-0808304-B1 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION SEARLE & CO (US) 2000-12-27 EP claimed
US-5916905-A ANTIARTHRITIC AGENTS; ANALGESICS; ANTIPYRETICS G. D. SEARLE & CO. (US) 1999-06-29 US claimed
EP-0659746-B1 Process for the preparation of sulfonylaminocarbonyl-triazolinones BAYER AG (DE) 1998-05-06 EP claimed
EP-0808304-A1 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1997-11-26 EP claimed
US-5686470-A 2, 3-substituted pyridines for the treatment of inflammation WEIER RICHARD M (US) 1997-11-11 US claimed
US-5550244-A Process for preparing sulphonylaminocarbonyltriazolinones BAYER AKTIENGESELLSCHAFT (DE) 1996-08-27 US claimed
WO-1996024584-A1 2,3-SUBSTITUTED PYRIDINES FOR THE TREATMENT OF INFLAMMATION G.D. SEARLE & CO. (US) 1996-08-15 WO claimed
EP-0659746-A1 Process for the preparation of sulfonylaminocarbonyl-triazolinones BAYER AG (DE) 1995-06-28 EP claimed
US-4886835-A ANTIINFLAMMATORY AGENTS RHONE-POULENC SANTE (FR) 1989-12-12 US claimed
EP-0310484-A1 Derivatives of alkadienes, their preparations, medicinal compositions containing them, and intermediates RHONE-POULENC SANTE (FR) 1989-04-05 EP claimed
US-4518596-A Antithrombotic use of 2-(perhydro-1,4-diazino)-pyrimido (5,4,D)-pyrimidines DR. KARL THOMAE GMBH (DE) 1985-05-21 US claimed
EP-0055444-B1 TRISUBSTITUTED PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM Dr. Karl Thomae GmbH (DE) 1985-03-20 EP claimed
EP-0023559-B1 2-(PERHYDRO-1,4-DIAZINO)-PYRIMIDO(5,4-D)PYRIMIDINES, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM Dr. Karl Thomae GmbH (DE) 1984-09-19 EP claimed
EP-0055444-A2 Trisubstituted pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them Dr. Karl Thomae GmbH (DE) 1982-07-07 EP claimed
EP-0023559-A1 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them Dr. Karl Thomae GmbH (DE) 1981-02-11 EP claimed
CN-115504896-B Acrylic formate compound for LED photopolymerization, preparation method and application thereof 湖北固润科技股份有限公司 2024-05-07 CN disclosed
WO-2024078413-A1 ACRYLOYL FORMATE COMPOUND FOR LED PHOTOPOLYMERIZATION, AND PREPARATION METHOD THEREFOR AND USE THEREOF 湖北固润科技股份有限公司 2024-04-18 WO disclosed
EP-0041170-A1 3-Nitro-pivaloyl-acetanilides, processes for their preparation and their utilization BAYER AG (DE) 1981-12-09 EP disclosed
EP-0023559-A1 2-(Perhydro-1,4-diazino)-pyrimido(5,4-d)pyrimidines, their preparation and medicaments containing them Dr. Karl Thomae GmbH (DE) 1981-02-11 EP disclosed