SCHEMBL2889991

SCHEMBL2889991

Cn1ccnc1SCCCSC(C)(C)C

nearest known ligand 0.47

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.45
KMT2A Q03164 4/20 0.40
ALDH1A1 P00352 5/20 0.40
RAB9A P51151 5/20 0.40
NPC1 O15118 5/20 0.40
MEN1 O00255 3/20 0.40
POLB P06746 3/20 0.40
MAPT P10636 2/20 0.40
HPGD P15428 2/20 0.40
TP53 P04637 1/20 0.40
ALOX12 P18054 1/20 0.40
HSD17B10 Q99714 1/20 0.40
GAA P10253 2/20 0.39
LMNA P02545 1/20 0.39
SMN1; SMN2 Q16637 4/20 0.39
TSHR P16473 1/20 0.39
ALPL P05186 1/20 0.38
ALPG P10696 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24866430 0.83 KDM4E (0.51) KDM4EKMT2AALDH1A1RAB9ANPC1
SCHEMBL9217653 0.80 KDM4E (0.49) KDM4EKMT2AALDH1A1RAB9ANPC1
SCHEMBL422525 0.80 KDM4E (0.49) KDM4EKMT2AALDH1A1RAB9ANPC1
Hydrochloric Acid SCHEMBL7448480 0.78 KDM4E (0.48) KDM4EKMT2AALDH1A1RAB9ANPC1
SCHEMBL7456376 0.78 KDM4E (0.48) KDM4EKMT2AALDH1A1RAB9ANPC1
SCHEMBL7814833 0.78 KDM4E (0.48) KDM4EKMT2AALDH1A1RAB9ANPC1
SCHEMBL12561746 0.78 KDM4E (0.48) KDM4EKMT2AALDH1A1RAB9ANPC1
SCHEMBL7357434 0.77 KDM4E (0.50) KDM4EKMT2AALDH1A1RAB9ANPC1
Bromide SCHEMBL11321862 0.77 KDM4E (0.47) KDM4EKMT2AALDH1A1RAB9ANPC1
SCHEMBL15219972 0.75 KDM4E (0.51) KDM4EKMT2AALDH1A1RAB9ANPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8932976-B2 Preparation of catalyst for bisphenols production DOW GLOBAL TECHNOLOGIES LLC (US) 2015-01-13 US disclosed
US-20100152028-A1 PREPARATION OF CATALYST FOR BISPHENOLS PRODUCTION DOW GLOBAL TECHNOLOGIES LLC 2010-06-17 US disclosed
US-6995294-B2 Method for producing bisphenol catalysts and bisphenols GENERAL ELECTRIC COMPANY (US) 2006-02-07 US disclosed
US-6992228-B2 Method for producing bisphenol catalysts and bisphenols GENERAL ELECTRIC COMPANY (US) 2006-01-31 US disclosed
US-20050090696-A1 Method for producing bisphenol catalysts and bisphenols SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2005-04-28 US disclosed
US-20050090697-A1 Method for producing bisphenol catalysts and bisphenols SABIC INNOVATIVE PLASTICS IP B.V. (NL) 2005-04-28 US disclosed
US-6884894-B2 Method for producing bisphenol catalysts and bisphenols GENERAL ELECTRIC COMPANY (US) 2005-04-26 US disclosed
US-6872860-B1 Method for producing bisphenol catalysts and bisphenols GENERAL ELECTRIC COMPANY (US) 2005-03-29 US disclosed
US-6620939-B2 Reacting phenol and acetone in the presence of acid catalysts or promoters such as 2-(3'-tert-butylthiopropylthioethyl)-pyridine on catalyst supports, to form isopropylidenediphenol; stereospecific GENERAL ELECTRIC COMPANY 2003-09-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050090697-A1 Method for producing bisphenol catalysts and bisphenols GSTP1, PCBP1, GSTA2 KDM4E 1535/4885KMT2A 1007/4885ALDH1A1 1497/4885
US-20050090696-A1 Method for producing bisphenol catalysts and bisphenols GSTP1, PCBP1, GSTA2 KDM4E 1535/4885KMT2A 1007/4885ALDH1A1 1497/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.