Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.68 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | TPMT | P51580 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | RCE1 | Q9Y256 | 2/20 | 0.41 |
| ▸ | CDC25B | P30305 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 3/20 | 0.41 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | THRB | P10828 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL988442 | 0.87 | TPMT (0.54) | KDM4ETDP1KMT2AMEN1TPMT | |
| SCHEMBL3097749 | 0.84 | TPMT (0.56) | KDM4ETDP1KMT2AMEN1TPMT | |
| Fluoride SCHEMBL11641082 | 0.82 | TPMT (0.54) | KDM4ETDP1KMT2AMEN1TPMT | |
| SCHEMBL28841032 | 0.82 | KDM4E (0.47) | KDM4ETDP1KMT2AMEN1ALDH1A1 | |
| SCHEMBL11644721 | 0.81 | KDM4E (0.70) | KDM4ETDP1KMT2AMEN1TPMT | |
| SCHEMBL2809942 | 0.81 | KDM4E (1.00) | KDM4ETDP1KMT2AMEN1TPMT | |
| SCHEMBL3252847 | 0.81 | KDM4E (0.48) | KDM4ETDP1KMT2AMEN1TPMT | |
| SCHEMBL2811286 | 0.79 | KDM4E (0.96) | KDM4ETDP1KMT2AMEN1TPMT | |
| SCHEMBL12640629 | 0.79 | KDM4E (0.52) | KDM4ETDP1KMT2AMEN1TPMT | |
| SCHEMBL6262459 | 0.79 | KDM4E (0.68) | KDM4ETDP1KMT2AMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107857755-A | N pyrrolidinyls, N` pyrazolyls urea, thiocarbamide, guanidine and cyanoguandine compounds as TRKA kinase inhibitors | 阵列生物制药公司 | 2018-03-30 | — | — | CN | disclosed |
| CN-106983751-A | Two ring substituted uracils and application thereof | 拜耳医药股份有限公司 | 2017-07-28 | — | — | CN | disclosed |
| CN-104395310-B | Bicyclic substituted uracils and their use | 拜耳药业股份公司 | 2017-05-03 | — | — | CN | disclosed |
| CN-105130967-A | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as trka kinase inhibitors | ARRAY BIOPHARMA INC | 2015-12-09 | — | — | CN | disclosed |
| CN-103649076-B | Pyrrolidinyl urea and pyrrolidinyl thiourea compounds as TRKA kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2015-09-09 | — | — | CN | disclosed |
| CN-104395310-A | Bicyclic substituted uracils and their use | Bayer Pharma AG | 2015-03-04 | — | — | CN | disclosed |
| CN-104147596-A | Method for prolonging treatment concentration by using non-covalent conjugated polymer of biological medicine and use | LI RONGXIU | 2014-11-19 | — | — | CN | disclosed |
| CN-102933545-B | Method of producing toluene dicarbamate, method of producing toluene diisocyanate, and toluene dicarbamate | MITSUI CHEMICALS INC | 2014-11-12 | — | — | CN | disclosed |
| CN-101617012-B | Aqueous coating composition having reduced plate out | ARKEMA | 2013-08-28 | — | — | CN | disclosed |
| CN-102933545-A | Method of producing toluene dicarbamate, method of producing toluene diisocyanate, and toluene dicarbamate | MITSUI CHEMICALS INC | 2013-02-13 | — | — | CN | disclosed |
| CN-101616977-B | Method for reducing plate out of aqueous coating compositions | DOW GLOBAL TECHNOLOGIES INC US | 2012-11-14 | — | — | CN | disclosed |
| US-20100286353-A1 | ACETYLENE COMPOUND, SALT THEREOF, CONDENSATE THEREOF, AND COMPOSITION THEREOF | FUJIFILM CORPORATION (JP) | 2010-11-11 | — | — | US | disclosed |
| EP-2202220-A1 | ACETYLENE COMPOUND, SALT THEREOF, CONDENSATE THEREOF, AND COMPOSITION THEREOF | Fujifilm Corporation (JP) | 2010-06-30 | — | — | EP | disclosed |
| CN-101616977-A | Be used to reduce the method for the incrustation of water-based paint compositions | DOW GLOBAL TECHNOLOGIES INC | 2009-12-30 | — | — | CN | disclosed |
| CN-101617012-A | Reduce the water-based paint compositions of incrustation | DOW GLOBAL TECHNOLOGIES INC | 2009-12-30 | — | — | CN | disclosed |
| CN-100372843-C | 2,5-disubstituted-1,3-dioxygen cycle compound, their synthesis and application as PKC inhibiter | CAPITAL MEDICAL UNIV (CN) | 2008-03-05 | — | — | CN | disclosed |
| CN-100366603-C | Process for preparing N-substituted carboxamides | LONZA AG (CH) | 2008-02-06 | — | — | CN | disclosed |
| CN-1785995-A | 2,5-disubstituted-1,3-dioxygen cycle compound, their synthesis and application as PKC inhibiter | CAPITAL MEDICAL UNIV (CN) | 2006-06-14 | — | — | CN | disclosed |
| CN-1751020-A | Process for the preparation of N-substituted formamides | LONZA AG (CH) | 2006-03-22 | — | — | CN | disclosed |
| CN-1242004-A | Process for making 2-amino-2-imidazoline, guanidine, and 2-amino-3,4,5,6-tetrahydropyrimidine derivatives | PROCTER & GAMBLE (US) | 2000-01-19 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100286353-A1 | ACETYLENE COMPOUND, SALT THEREOF, CONDENSATE THEREOF, AND COMPOSITION THEREOF | KAT8, HDAC10, SSRP1 | KDM4E 3239/4885TDP1 4001/4885KMT2A 583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.