Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 17/20 | 0.51 |
| ▸ | GSK3B | P49841 | 17/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.38 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
| ▸ | HRH4 | Q9H3N8 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28911715 | 0.85 | GSK3A (0.46) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL20205218 | 0.85 | GSK3B (0.70) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL28911752 | 0.84 | GSK3A (0.49) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL28911768 | 0.83 | GSK3B (0.46) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL28911703 | 0.83 | GSK3A (0.47) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL28911794 | 0.81 | GSK3A (0.70) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL28911698 | 0.81 | GSK3A (0.47) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL28911737 | 0.81 | GSK3A (0.46) | GSK3AGSK3BPIM1 | |
| SCHEMBL28961191 | 0.80 | GSK3A (0.59) | GSK3AGSK3BJAK2PIM1CDK2 | |
| SCHEMBL28911729 | 0.80 | GSK3A (0.64) | GSK3AGSK3BJAK2PIM1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110545817-B | GSK-3 inhibitors | 百时美施贵宝公司 | 2022-11-15 | — | — | CN | disclosed |