Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 16/20 | 0.48 |
| ▸ | GSK3A | P49840 | 15/20 | 0.48 |
| ▸ | PIM1 | P11309 | 5/20 | 0.43 |
| ▸ | CDK2 | P24941 | 3/20 | 0.43 |
| ▸ | JAK2 | O60674 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.40 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.39 |
| ▸ | PIM2 | Q9P1W9 | 2/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28911783 | 0.90 | GSK3A (0.56) | GSK3BGSK3APIM1CDK2JAK2 | |
| SCHEMBL28911710 | 0.89 | GSK3B (0.51) | GSK3BGSK3APIM1CDK2JAK2 | |
| SCHEMBL28911773 | 0.89 | GSK3A (0.53) | GSK3BGSK3AAURKBHDAC1 | |
| SCHEMBL20204977 | 0.85 | GSK3B (0.67) | GSK3BGSK3APIM1CDK2JAK2 | |
| SCHEMBL28911707 | 0.84 | GSK3B (0.56) | GSK3BGSK3APIM1CDK2JAK2 | |
| SCHEMBL28960743 | 0.84 | GSK3A (0.51) | GSK3BGSK3APIM1CDK2JAK2 | |
| SCHEMBL28911741 | 0.84 | GSK3B (0.52) | GSK3BGSK3APIM1CDK2JAK2 | |
| SCHEMBL28911743 | 0.83 | GSK3A (0.61) | GSK3BGSK3APIM1CDK2JAK2 | |
| SCHEMBL28911763 | 0.81 | GSK3A (0.53) | GSK3BGSK3APIM1CDK2JAK2 | |
| SCHEMBL28911730 | 0.81 | GSK3A (0.49) | GSK3BGSK3APIM1CDK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110545817-B | GSK-3 inhibitors | 百时美施贵宝公司 | 2022-11-15 | — | — | CN | disclosed |