Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 6/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 3/20 | 0.33 |
| ▸ | GLS | O94925 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.31 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.31 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.31 |
| ▸ | PPARG | P37231 | 2/20 | 0.31 |
| ▸ | PPARD | Q03181 | 2/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26113148 | 0.93 | BTK (0.40) | BTKCRBNEGFRMAPT | |
| SCHEMBL26114090 | 0.86 | BTK (0.46) | BTKCRBNEGFRGLSMAPT | |
| SCHEMBL28961423 | 0.81 | BTK (0.43) | BTKEGFR | |
| SCHEMBL28915516 | 0.77 | BTK (0.38) | BTKEGFRMAPT | |
| Hydrochloric Acid SCHEMBL30064453 | 0.75 | BTK (0.48) | BTKCRBNBMPR1BACVRL1ACVR1 | |
| Hydrochloric Acid SCHEMBL26116546 | 0.75 | BTK (0.48) | BTKCRBNBMPR1BACVRL1ACVR1 | |
| SCHEMBL23816440 | 0.74 | BTK (0.42) | BTKEGFR | |
| SCHEMBL23816148 | 0.73 | BTK (0.39) | BTKEGFR | |
| SCHEMBL28915529 | 0.73 | BTK (0.45) | BTKEGFR | |
| SCHEMBL23816019 | 0.70 | BTK (0.53) | BTKCRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115335376-A | Degradation of Bruton's Tyrosine Kinase (BTK) by conjugation of BTK inhibitor with E3 ligase ligand and methods of use thereof | 百济神州有限公司 | 2022-11-11 | — | — | CN | disclosed |