Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 2/20 | 0.47 |
| ▸ | EZH2 | Q15910 | 12/20 | 0.46 |
| ▸ | EED | O75530 | 1/20 | 0.45 |
| ▸ | RBBP4 | Q09028 | 1/20 | 0.45 |
| ▸ | SUZ12 | Q15022 | 1/20 | 0.45 |
| ▸ | AEBP2 | Q6ZN18 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29473812 | 1.00 | ITK (0.47) | ITKEZH2EEDRBBP4SUZ12 | |
| SCHEMBL29473810 | 0.81 | EZH2 (0.42) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL28600937 | 0.81 | EZH2 (0.42) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL28598403 | 0.79 | EZH2 (0.45) | ITKEZH2EEDRBBP4SUZ12 | |
| SCHEMBL29473787 | 0.79 | EZH2 (0.45) | ITKEZH2EEDRBBP4SUZ12 | |
| SCHEMBL28594985 | 0.78 | ITK (0.45) | ITKMAPK8NAMPT | |
| SCHEMBL29473794 | 0.78 | ITK (0.45) | ITKMAPK8NAMPT | |
| SCHEMBL28600423 | 0.77 | EZH2 (0.41) | EZH2NAMPT | |
| SCHEMBL29473802 | 0.77 | EZH2 (0.41) | EZH2NAMPT | |
| SCHEMBL29473811 | 0.76 | NAMPT (0.42) | ITKNAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113045494-B | Pyridone derivative and application thereof in preparation of drugs for preventing and/or treating tuberculosis caused by mycobacterium tuberculosis | 四川大学华西医院 | 2022-04-26 | — | — | CN | disclosed |
| CN-113045494-A | Pyridone derivative and application thereof in preparation of drugs for preventing and/or treating tuberculosis caused by mycobacterium tuberculosis | 四川大学华西医院 | 2021-06-29 | — | — | CN | disclosed |