Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 19/20 | 0.68 |
| ▸ | MAP3K9 | P80192 | 1/20 | 0.65 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.65 |
| ▸ | IGF1R | P08069 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25820550 | 0.92 | LRRK2 (0.70) | LRRK2MAP3K9MKNK2IGF1RKCNH2 | |
| SCHEMBL25820390 | 0.92 | LRRK2 (0.69) | LRRK2MAP3K9MKNK2IGF1RKCNH2 | |
| SCHEMBL25820433 | 0.92 | LRRK2 (0.69) | LRRK2MAP3K9MKNK2IGF1RKCNH2 | |
| SCHEMBL25820554 | 0.91 | LRRK2 (0.68) | LRRK2MAP3K9MKNK2IGF1RKCNH2 | |
| SCHEMBL25820400 | 0.91 | LRRK2 (0.68) | LRRK2MAP3K9MKNK2IGF1RKCNH2 | |
| SCHEMBL25820475 | 0.90 | LRRK2 (0.68) | LRRK2MAP3K9MKNK2IGF1RKCNH2 | |
| SCHEMBL25820396 | 0.90 | LRRK2 (0.66) | LRRK2MAP3K9MKNK2IGF1RKCNH2 | |
| SCHEMBL30082594 | 0.89 | LRRK2 (0.74) | LRRK2MAP3K9MKNK2IGF1RKCNH2 | |
| SCHEMBL25821301 | 0.89 | LRRK2 (0.74) | LRRK2MAP3K9MKNK2IGF1RKCNH2 | |
| SCHEMBL25820435 | 0.89 | LRRK2 (0.65) | LRRK2MAP3K9MKNK2IGF1RKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115413278-A | Novel pyrimidine derivative and composition for preventing or treating neurodegenerative disease and cancer comprising same | 丸仁制药株式会社 | 2022-11-29 | — | — | CN | claimed |
| CN-115413278-A | Novel pyrimidine derivative and composition for preventing or treating neurodegenerative disease and cancer comprising same | 丸仁制药株式会社 | 2022-11-29 | — | — | CN | disclosed |