Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.64 |
| ▸ | MET | P08581 | 7/20 | 0.64 |
| ▸ | TEK | Q02763 | 7/20 | 0.64 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.64 |
| ▸ | AURKA | O14965 | 5/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 6/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.64 |
| ▸ | RET | P07949 | 4/20 | 0.64 |
| ▸ | KIT | P10721 | 2/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.64 |
| ▸ | FLT1 | P17948 | 2/20 | 0.64 |
| ▸ | FLT4 | P35916 | 2/20 | 0.64 |
| ▸ | ABL1 | P00519 | 2/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.64 |
| ▸ | ERN1 | O75460 | 1/20 | 0.64 |
| ▸ | STK10 | O94804 | 1/20 | 0.64 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.64 |
| ▸ | ESR1 | P03372 | 1/20 | 0.64 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.64 |
| ▸ | BCR | P11274 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19072655 | 0.88 | KDR (0.67) | KDRMETTEKAURKBAURKA | |
| SCHEMBL1889410 | 0.88 | KDR (0.67) | KDRMETTEKAURKBAURKA | |
| SCHEMBL29624485 | 0.88 | KDR (0.67) | KDRMETTEKAURKBAURKA | |
| Hydrochloric Acid SCHEMBL28030463 | 0.87 | KDR (0.66) | KDRMETTEKAURKBAURKA | |
| Water SCHEMBL19056904 | 0.87 | KDR (0.66) | KDRMETTEKAURKBAURKA | |
| SCHEMBL30785072 | 0.87 | KDR (0.66) | KDRMETTEKAURKBAURKA | |
| SCHEMBL28630537 | 0.87 | KDR (0.66) | KDRMETTEKAURKBAURKA | |
| SCHEMBL28636083 | 0.86 | KDR (0.66) | KDRMETTEKAURKBAURKA | |
| SCHEMBL26726698 | 0.85 | KDR (0.73) | KDRMETTEKAURKBAURKA | |
| SCHEMBL23366513 | 0.84 | KDR (0.83) | KDRMETTEKAURKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115572261-A | Method for removing impurities of varlitinib mesylate | 江苏省肿瘤医院 | 2023-01-06 | — | — | CN | claimed |
| CN-115572261-A | Method for removing impurities of varlitinib mesylate | 江苏省肿瘤医院 | 2023-01-06 | — | — | CN | disclosed |
| CN-115572261-A | Method for removing impurities of varlitinib mesylate | 江苏省肿瘤医院 | 2023-01-06 | — | — | CN | disclosed |