Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 6/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.36 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.34 |
| ▸ | FEN1 | P39748 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ITK | Q08881 | 1/20 | 0.34 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | RAF1 | P04049 | 1/20 | 0.34 |
| ▸ | BRAF | P15056 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30411121 | 0.85 | MKNK2 (0.42) | MKNK2SYKPCSK9RAF1BRAF | |
| SCHEMBL22105604 | 0.84 | MKNK2 (0.41) | MKNK2PCSK9RAF1BRAF | |
| SCHEMBL30184391 | 0.83 | MKNK2 (0.42) | MKNK2PCSK9ALOX5APFEN1RAF1 | |
| SCHEMBL22105605 | 0.83 | MKNK2 (0.41) | MKNK2PCSK9 | |
| SCHEMBL28928900 | 0.83 | MKNK2 (0.42) | MKNK2PCSK9ALOX5APFEN1RAF1 | |
| SCHEMBL25117838 | 0.83 | MKNK2 (0.42) | MKNK2PCSK9ALOX5APFEN1RAF1 | |
| SCHEMBL25174250 | 0.83 | GRM5 (0.40) | MKNK2PCSK9CYP3A4ALOX5APFEN1 | |
| SCHEMBL30309832 | 0.83 | GRM5 (0.40) | MKNK2PCSK9CYP3A4ALOX5APFEN1 | |
| SCHEMBL25117791 | 0.83 | GRM5 (0.40) | MKNK2PCSK9CYP3A4ALOX5APFEN1 | |
| SCHEMBL25117835 | 0.81 | MKNK2 (0.39) | MKNK2SYKPCSK9CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113754682-B | Compound having macrocyclic structure and use thereof | 赛诺哈勃药业（成都）有限公司 | 2023-01-06 | — | — | CN | disclosed |
| CN-113754682-A | Compounds having macrocyclic structure and uses thereof | 成都倍特药业股份有限公司 | 2021-12-07 | — | — | CN | disclosed |