Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.39 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.39 |
| ▸ | GABRD | O14764 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.39 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.39 |
| ▸ | GABRE | P78334 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17750114 | 0.86 | NOTUM (0.47) | NOTUMCYP1A2ALDH1A1KDM4EHPGD | |
| SCHEMBL29215881 | 0.86 | NOTUM (0.47) | NOTUMCYP1A2ALDH1A1KDM4EHPGD | |
| SCHEMBL29215889 | 0.86 | NOTUM (0.47) | NOTUMCYP1A2ALDH1A1KDM4EHPGD | |
| SCHEMBL12458255 | 0.86 | NOTUM (0.49) | NOTUMCYP1A2ALDH1A1KDM4EHPGD | |
| SCHEMBL15148626 | 0.83 | NOTUM (0.47) | NOTUMCYP1A2ALDH1A1KDM4EHPGD | |
| SCHEMBL28934504 | 0.83 | NOTUM (0.47) | NOTUMCYP1A2ALDH1A1KDM4EHPGD | |
| SCHEMBL15148680 | 0.83 | NOTUM (0.47) | NOTUMCYP1A2ALDH1A1KDM4EHPGD | |
| SCHEMBL28934505 | 0.83 | NOTUM (0.47) | NOTUMCYP1A2ALDH1A1KDM4EHPGD | |
| SCHEMBL21026472 | 0.83 | NOTUM (0.47) | NOTUMCYP1A2ALDH1A1KDM4EHPGD | |
| SCHEMBL29215901 | 0.82 | NOTUM (0.46) | NOTUMCYP1A2ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115461338-B | 3-azabicyclo (3.1.0) hexane derivatives having KDM5 inhibitory activity and uses thereof | 小野药品工业株式会社 | 2024-02-20 | — | — | CN | disclosed |
| EP-4146645-A1 | 3-AZABICYCLO(3.1.0)HEXANE DERIVATIVES HAVING KDM5 INHIBITORY ACTIVITY AND USE THEREOF | ONO Pharmaceutical Co., Ltd. (JP) | 2023-03-15 | — | — | EP | disclosed |
| CN-115461338-A | 3-azabicyclo (3.1.0) hexane derivatives having KDM5 inhibitory activity and uses thereof | 小野药品工业株式会社 | 2022-12-09 | — | — | CN | disclosed |