Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | GFER | P55789 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | HSF1 | Q00613 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | JAK1 | P23458 | 2/20 | 0.46 |
| ▸ | TYK2 | P29597 | 2/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.44 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.44 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29919717 | 1.00 | MEN1 (0.50) | MEN1MAPK10GFERKMT2ACCNE1 | |
| SCHEMBL10172152 | 0.79 | NPC1 (0.47) | MEN1KMT2ANPC1JAK2TYK2 | |
| SCHEMBL29391624 | 0.78 | KMT2A (0.76) | MEN1MAPK10GFERKMT2ANPC1 | |
| SCHEMBL221242 | 0.78 | KMT2A (0.76) | MEN1MAPK10GFERKMT2ANPC1 | |
| SCHEMBL857502 | 0.78 | NPC1 (0.63) | MEN1KMT2ACDK2NPC1EGFR | |
| SCHEMBL16926547 | 0.78 | MEN1 (0.53) | MEN1MAPK10GFERKMT2ANPC1 | |
| SCHEMBL4595845 | 0.77 | KMT2A (0.48) | MEN1MAPK10GFERKMT2ACDK2 | |
| SCHEMBL29919765 | 0.77 | NPC1 (0.46) | MEN1KMT2ANPC1JAK2TYK2 | |
| SCHEMBL28936138 | 0.77 | NPC1 (0.46) | MEN1KMT2ANPC1JAK2TYK2 | |
| SCHEMBL31247411 | 0.77 | NPC1 (0.50) | MEN1KMT2ALCKNPC1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109020957-B | Heterocyclic compounds as MNK inhibitors | 南京天印健华医药科技有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |