Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 16/20 | 0.62 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29919723 | 1.00 | MKNK1 (0.62) | MKNK1AXLROCK2RETKDR | |
| SCHEMBL28936119 | 0.87 | MKNK1 (0.66) | MKNK1AXLROCK2 | |
| SCHEMBL28936150 | 0.87 | MKNK1 (0.62) | MKNK1AXLROCK2 | |
| SCHEMBL29919828 | 0.86 | MKNK1 (0.59) | MKNK1AXLROCK2 | |
| SCHEMBL28936250 | 0.86 | MKNK1 (0.59) | MKNK1AXLROCK2 | |
| SCHEMBL28936173 | 0.85 | MKNK1 (0.58) | MKNK1ROCK2 | |
| SCHEMBL29919595 | 0.85 | MKNK1 (0.58) | MKNK1ROCK2 | |
| SCHEMBL28936177 | 0.85 | MKNK1 (0.61) | MKNK1AXLROCK2 | |
| SCHEMBL29919796 | 0.84 | MKNK1 (0.57) | MKNK1AXLROCK2 | |
| SCHEMBL28936080 | 0.84 | MKNK1 (0.57) | MKNK1AXLROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109020957-B | Heterocyclic compounds as MNK inhibitors | 南京天印健华医药科技有限公司（CN） | 2023-01-13 | — | — | CN | disclosed |