Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 10/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.38 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.35 |
| ▸ | XDH | P47989 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23832239 | 1.00 | CYP11B1 (0.41) | CYP11B1LRRK2CYP11B2MRGPRX4FFAR1 | |
| SCHEMBL23832375 | 1.00 | CYP11B1 (0.41) | CYP11B1LRRK2CYP11B2MRGPRX4FFAR1 | |
| SCHEMBL23839956 | 0.85 | CYP11B1 (0.41) | CYP11B1LRRK2CYP11B2MRGPRX4 | |
| SCHEMBL23832273 | 0.84 | CYP11B1 (0.47) | CYP11B1CYP11B2MRGPRX4ESR1RAB9A | |
| SCHEMBL23832237 | 0.83 | CYP11B1 (0.39) | CYP11B1CYP11B2GPR35 | |
| SCHEMBL30144843 | 0.83 | CYP11B1 (0.46) | CYP11B1CYP11B2MRGPRX4GPR35 | |
| SCHEMBL23839934 | 0.83 | CYP11B1 (0.46) | CYP11B1CYP11B2MRGPRX4GPR35 | |
| SCHEMBL23832202 | 0.82 | CYP11B1 (0.43) | CYP11B1LRRK2CYP11B2SLC22A12 | |
| SCHEMBL28253857 | 0.82 | CYP11B1 (0.43) | CYP11B1LRRK2CYP11B2SLC22A12 | |
| SCHEMBL23832227 | 0.81 | CYP11B1 (0.43) | CYP11B1CYP11B2MRGPRX4XDHSLC22A12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115605467-A | PHD inhibitor compounds, compositions and uses thereof | 阿克比治疗有限公司（US） | 2023-01-13 | — | — | CN | disclosed |
| CN-115551845-A | PHD inhibitor compounds, compositions and uses | 阿克比治疗有限公司 | 2022-12-30 | — | — | CN | disclosed |