Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 14/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29557919 | 1.00 | MAP4K1 (0.49) | MAP4K1ALKPTK2GRK5IGF1R | |
| SCHEMBL28719690 | 0.91 | MAP4K1 (0.42) | MAP4K1ALKPTK2IGF1R | |
| SCHEMBL29557662 | 0.91 | MAP4K1 (0.42) | MAP4K1ALKPTK2IGF1R | |
| SCHEMBL28937692 | 0.90 | MAP4K1 (0.44) | MAP4K1ALKPTK2 | |
| SCHEMBL29557921 | 0.90 | MAP4K1 (0.51) | MAP4K1ALKPTK2GRK5IGF1R | |
| SCHEMBL28720834 | 0.90 | MAP4K1 (0.51) | MAP4K1ALKPTK2GRK5IGF1R | |
| SCHEMBL28717640 | 0.89 | MAP4K1 (0.46) | MAP4K1ALKPTK2 | |
| SCHEMBL29557880 | 0.89 | MAP4K1 (0.46) | MAP4K1ALKPTK2 | |
| SCHEMBL28717557 | 0.88 | MAP4K1 (0.51) | MAP4K1ALKPTK2 | |
| SCHEMBL29558016 | 0.88 | MAP4K1 (0.51) | MAP4K1ALKPTK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114315796-B | Compounds used as HPK1 kinase inhibitor, preparation method and application thereof | 中国药科大学 | 2024-03-26 | — | — | CN | disclosed |
| CN-114315796-A | Compound used as HPK1 kinase inhibitor and preparation method and application thereof | 中国药科大学 | 2022-04-12 | — | — | CN | disclosed |