Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.77 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.49 |
| ▸ | CPT1A | P50416 | 1/20 | 0.47 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28943276 | 1.00 | TRPV1 (0.77) | TRPV1TRPM8ALDH1A1HPGDTSHR | |
| SCHEMBL30212118 | 1.00 | TRPV1 (0.77) | TRPV1TRPM8ALDH1A1HPGDTSHR | |
| SCHEMBL28943335 | 0.86 | TRPV1 (0.66) | TRPV1TRPM8POLBAADATCPT1A | |
| SCHEMBL28943334 | 0.86 | TRPV1 (0.66) | TRPV1TRPM8POLBAADATCPT1A | |
| SCHEMBL28943343 | 0.84 | TRPV1 (0.72) | TRPV1TRPM8POLBAADATCPT1A | |
| SCHEMBL28943340 | 0.84 | TRPV1 (0.72) | TRPV1TRPM8POLBAADATCPT1A | |
| SCHEMBL28963951 | 0.83 | TRPV1 (0.72) | TRPV1TRPM8ALDH1A1TSHRPOLB | |
| SCHEMBL28963950 | 0.83 | TRPV1 (0.72) | TRPV1TRPM8ALDH1A1TSHRPOLB | |
| SCHEMBL30212113 | 0.83 | TRPV1 (0.72) | TRPV1TRPM8ALDH1A1TSHRPOLB | |
| SCHEMBL28943292 | 0.82 | TRPV1 (0.70) | TRPV1TRPM8ALDH1A1POLBAADAT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423432-B | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2023-01-24 | — | — | CN | claimed |
| CN-111423432-A | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423432-B | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2023-01-24 | — | — | CN | disclosed |
| CN-111423432-A | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2020-07-17 | — | — | CN | disclosed |