Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 9/20 | 0.69 |
| ▸ | CPT1A | P50416 | 10/20 | 0.54 |
| ▸ | CPT2 | P23786 | 6/20 | 0.47 |
| ▸ | CPT1B | Q92523 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28943282 | 1.00 | TRPV1 (0.69) | TRPV1CPT1ACPT2CPT1B | |
| SCHEMBL28943401 | 0.87 | TRPV1 (0.82) | TRPV1CPT1ACPT2CPT1B | |
| SCHEMBL28943403 | 0.87 | TRPV1 (0.82) | TRPV1CPT1ACPT2CPT1B | |
| SCHEMBL28943393 | 0.86 | TRPV1 (0.63) | TRPV1CPT1ACPT2 | |
| SCHEMBL28943390 | 0.86 | TRPV1 (0.63) | TRPV1CPT1ACPT2 | |
| SCHEMBL28943342 | 0.83 | TRPV1 (0.77) | TRPV1CPT1ACPT2CPT1B | |
| SCHEMBL28943345 | 0.83 | TRPV1 (0.77) | TRPV1CPT1ACPT2CPT1B | |
| SCHEMBL28943406 | 0.83 | TRPV1 (0.68) | TRPV1CPT1ACPT2CPT1B | |
| SCHEMBL28943405 | 0.83 | TRPV1 (0.68) | TRPV1CPT1ACPT2CPT1B | |
| SCHEMBL28943283 | 0.80 | TRPV1 (0.70) | TRPV1CPT1ACPT2CPT1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111423432-B | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2023-01-24 | — | — | CN | claimed |
| CN-111423432-A | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2020-07-17 | — | — | CN | claimed |
| CN-111423432-B | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2023-01-24 | — | — | CN | disclosed |
| CN-111423432-A | (S) -4/5-phenyl-2- (pyrrolidine-2-yl) thiazole TRPV1 antagonist and preparation and application thereof | 河南大学 | 2020-07-17 | — | — | CN | disclosed |