SCHEMBL28944487

SCHEMBL28944487

CC(C)(C)OC(=O)NCCCNC(=O)c1csc(-c2csc(CCOC(N)=O)n2)n1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC3 O15379 8/20 0.62
HDAC1 Q13547 8/20 0.62
HDAC6 Q9UBN7 7/20 0.62
ACKR3 P25106 1/20 0.41
HPGDS O60760 1/20 0.38
ABCB1 P08183 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
STK17B O94768 1/20 0.35
STK17A Q9UEE5 1/20 0.35
TDP1 Q9NUW8 1/20 0.35
MAOA P21397 1/20 0.34
MAOB P27338 1/20 0.34
CA12 O43570 2/20 0.34
CA1 P00915 2/20 0.34
CA2 P00918 2/20 0.34
CA9 Q16790 2/20 0.34
PI4KB Q9UBF8 1/20 0.34
CYP1A2 P05177 1/20 0.34
POLB P06746 1/20 0.34
CYP3A4 P08684 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24780896 0.89 HDAC3 (0.66) HDAC3HDAC1HDAC6ACKR3HPGDS
SCHEMBL23164198 0.86 HDAC1 (0.65) HDAC3HDAC1HDAC6ACKR3HPGDS
SCHEMBL24780895 0.82 HDAC3 (0.65) HDAC3HDAC1HDAC6ACKR3HPGDS
SCHEMBL23164203 0.79 HDAC3 (0.58) HDAC3HDAC1HDAC6ACKR3HPGDS
SCHEMBL30110696 0.79 HDAC3 (0.54) HDAC3HDAC1HDAC6ACKR3HPGDS
SCHEMBL24781178 0.78 HDAC3 (0.64) HDAC3HDAC1HDAC6ACKR3HPGDS
SCHEMBL15580221 0.76 HDAC3 (1.00) HDAC3HDAC1HDAC6
SCHEMBL15580303 0.76 HDAC3 (1.00) HDAC3HDAC1HDAC6
SCHEMBL15580274 0.76 HDAC3 (1.00) HDAC3HDAC1HDAC6
SCHEMBL28780520 0.75 HDAC3 (0.59) HDAC3HDAC1HDAC6ACKR3HPGDS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114599662-A Neomycin-based compounds and pharmaceutical uses thereof 蔚蓝海岸大学 2022-06-07 CN disclosed