Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 19/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 18/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 18/20 | 0.55 |
| ▸ | CLK4 | Q9HAZ1 | 17/20 | 0.55 |
| ▸ | DYRK2 | Q92630 | 16/20 | 0.55 |
| ▸ | CLK2 | P49760 | 15/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 14/20 | 0.55 |
| ▸ | CLK3 | P49761 | 12/20 | 0.52 |
| ▸ | DYRK4 | Q9NR20 | 10/20 | 0.52 |
| ▸ | GSK3B | P49841 | 7/20 | 0.52 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.46 |
| ▸ | CSNK2A1 | P68400 | 3/20 | 0.46 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PRKCB | P05771 | 1/20 | 0.45 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.45 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.45 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29899874 | 0.93 | CLK1 (0.56) | CLK1DYRK1ADYRK1BCLK4DYRK2 | |
| SCHEMBL28843078 | 0.93 | CLK1 (0.56) | CLK1DYRK1ADYRK1BCLK4DYRK2 | |
| SCHEMBL23510749 | 0.93 | CLK1 (0.56) | CLK1DYRK1ADYRK1BCLK4DYRK2 | |
| SCHEMBL29899934 | 0.87 | CLK1 (0.52) | CLK1DYRK1ADYRK1BCLK4DYRK2 | |
| SCHEMBL23510700 | 0.87 | CLK1 (0.52) | CLK1DYRK1ADYRK1BCLK4DYRK2 | |
| SCHEMBL28842939 | 0.87 | CLK1 (0.52) | CLK1DYRK1ADYRK1BCLK4DYRK2 | |
| SCHEMBL23510747 | 0.87 | CLK1 (0.52) | CLK1DYRK1ADYRK1BCLK4DYRK2 | |
| SCHEMBL28842943 | 0.87 | CLK1 (0.52) | CLK1DYRK1ADYRK1BCLK4DYRK2 | |
| SCHEMBL29899859 | 0.87 | CLK1 (0.52) | CLK1DYRK1ADYRK1BCLK4DYRK2 | |
| SCHEMBL23510632 | 0.87 | CLK1 (0.62) | CLK1DYRK1ADYRK1BCLK4DYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115515953-A | Novel imidazolidinone derivatives as inhibitors of protein kinases, in particular DYRK1A, CLK1 and/or CLK4 | 珀哈制药公司 | 2022-12-23 | — | — | CN | claimed |
| CN-115515953-A | Novel imidazolidinone derivatives as inhibitors of protein kinases, in particular DYRK1A, CLK1 and/or CLK4 | 珀哈制药公司 | 2022-12-23 | — | — | CN | disclosed |