Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 20/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 20/20 | 0.58 |
| ▸ | CLK2 | P49760 | 19/20 | 0.58 |
| ▸ | DYRK3 | O43781 | 18/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 18/20 | 0.58 |
| ▸ | DYRK2 | Q92630 | 18/20 | 0.58 |
| ▸ | DYRK1B | Q9Y463 | 18/20 | 0.58 |
| ▸ | CLK3 | P49761 | 16/20 | 0.58 |
| ▸ | DYRK4 | Q9NR20 | 15/20 | 0.58 |
| ▸ | GSK3B | P49841 | 12/20 | 0.58 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23970202 | 1.00 | CLK1 (0.58) | CLK1CLK4CLK2DYRK3DYRK1A | |
| SCHEMBL25590009 | 1.00 | CLK1 (0.58) | CLK1CLK4CLK2DYRK3DYRK1A | |
| SCHEMBL28945508 | 1.00 | CLK1 (0.58) | CLK1CLK4CLK2DYRK3DYRK1A | |
| SCHEMBL28945515 | 0.98 | CLK1 (0.58) | CLK1CLK4CLK2DYRK3DYRK1A | |
| SCHEMBL23970204 | 0.98 | CLK1 (0.58) | CLK1CLK4CLK2DYRK3DYRK1A | |
| SCHEMBL23970256 | 0.98 | CLK1 (0.58) | CLK1CLK4CLK2DYRK3DYRK1A | |
| SCHEMBL28964076 | 0.98 | CLK1 (0.58) | CLK1CLK4CLK2DYRK3DYRK1A | |
| SCHEMBL30144959 | 0.93 | CLK1 (0.58) | CLK1CLK4CLK2DYRK3DYRK1A | |
| SCHEMBL28945444 | 0.93 | CLK1 (0.58) | CLK1CLK4CLK2DYRK3DYRK1A | |
| SCHEMBL30144893 | 0.93 | CLK1 (0.58) | CLK1CLK4CLK2DYRK3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115515953-A | Novel imidazolidinone derivatives as inhibitors of protein kinases, in particular DYRK1A, CLK1 and/or CLK4 | 珀哈制药公司 | 2022-12-23 | — | — | CN | disclosed |