Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSC | P53634 | 19/20 | 0.75 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.75 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.75 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.75 |
| ▸ | CTSK | P43235 | 2/20 | 0.56 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289455 | 1.00 | CTSC (0.75) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL31758077 | 0.90 | CTSC (0.76) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL31757875 | 0.90 | CTSC (0.76) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL2890855 | 0.86 | CTSC (1.00) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL2890859 | 0.86 | CTSC (1.00) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| Dioxane SCHEMBL2891129 | 0.85 | CTSC (0.98) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL289849 | 0.85 | CTSC (0.63) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL289850 | 0.85 | CTSC (0.63) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL2885767 | 0.84 | CTSC (0.73) | CTSCKCNH2LTB4RLTB4R2CTSK | |
| SCHEMBL2885769 | 0.84 | CTSC (0.73) | CTSCKCNH2LTB4RLTB4R2CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2427445-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | AstraZeneca AB (SE) | 2012-03-14 | — | — | EP | claimed |
| WO-2010128324-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | WO | claimed |
| EP-2427445-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | AstraZeneca AB (SE) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010128324-A1 | SUBSTITUTED 1-CYANOETHYLHETEROCYCLYLCARBOXAMIDE COMPOUNDS 750 | ASTRAZENECA AB (SE) | 2010-11-11 | — | — | WO | disclosed |