Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | JAK3 | P52333 | 3/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | IGF1R | P08069 | 2/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 6/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 2/20 | 0.35 |
| ▸ | CDK7 | P50613 | 2/20 | 0.35 |
| ▸ | CDK9 | P50750 | 2/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 2/20 | 0.35 |
| ▸ | CDK1 | P06493 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30086710 | 0.87 | JAK2 (0.38) | JAK2JAK3EGFRIGF1RIKBKB | |
| SCHEMBL23906589 | 0.87 | JAK2 (0.38) | JAK2JAK3EGFRIGF1RIKBKB | |
| SCHEMBL30086326 | 0.85 | WEE1 (0.45) | JAK2JAK3EGFRIGF1RAURKA | |
| SCHEMBL25251761 | 0.85 | WEE1 (0.45) | JAK2JAK3EGFRIGF1RAURKA | |
| SCHEMBL30086481 | 0.85 | WEE1 (0.45) | JAK2JAK3EGFRIGF1RAURKA | |
| SCHEMBL25251762 | 0.85 | WEE1 (0.45) | JAK2JAK3EGFRIGF1RAURKA | |
| SCHEMBL25221254 | 0.85 | WEE1 (0.45) | JAK2JAK3EGFRIGF1RAURKA | |
| SCHEMBL23906696 | 0.85 | WEE1 (0.39) | JAK2JAK3EGFRIGF1RAURKA | |
| SCHEMBL30086317 | 0.85 | WEE1 (0.39) | JAK2JAK3EGFRIGF1RAURKA | |
| SCHEMBL23906537 | 0.85 | WEE1 (0.39) | JAK2JAK3EGFRIGF1RAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115443269-A | Substituted pyrimidines and methods of use | 施万生物制药研发IP有限责任公司 | 2022-12-06 | — | — | CN | disclosed |