Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 18/20 | 0.54 |
| ▸ | AURKA | O14965 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.46 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28969639 | 0.93 | PTK2 (0.54) | PTK2AURKA | |
| SCHEMBL30184426 | 0.93 | PTK2 (0.54) | PTK2AURKA | |
| SCHEMBL24752245 | 0.92 | PTK2 (0.57) | PTK2JAK2NTRK1TYK2KDR | |
| SCHEMBL30002235 | 0.92 | PTK2 (0.57) | PTK2JAK2NTRK1TYK2KDR | |
| SCHEMBL28969593 | 0.90 | AURKA (0.57) | PTK2AURKAJAK2NTRK2 | |
| SCHEMBL24752251 | 0.90 | PTK2 (0.55) | PTK2NTRK2 | |
| SCHEMBL30002994 | 0.90 | PTK2 (0.55) | PTK2NTRK2 | |
| SCHEMBL24752249 | 0.88 | AURKA (0.58) | PTK2AURKAJAK2 | |
| SCHEMBL24752678 | 0.88 | PTK2 (0.69) | PTK2 | |
| SCHEMBL30184428 | 0.88 | AURKA (0.58) | PTK2AURKAJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116870016-B | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2024-05-28 | — | — | CN | disclosed |
| CN-117412981-A | Phosphine oxide derivative and preparation method and application thereof | 希格生科（深圳）有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-116870016-A | Heteroaromatic compound and medical application thereof | 希格生科（深圳）有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-115785154-A | Heteroaromatic ring compounds and medical use thereof | 希格生科（深圳）有限公司 | 2023-03-14 | — | — | CN | disclosed |