Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 6/20 | 0.52 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.48 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.48 |
| ▸ | ITGAL | P20701 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PYGL | P06737 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2904442 | 0.93 | GPR183 (0.52) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL2904444 | 0.93 | GPR183 (0.52) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL2903206 | 0.92 | GPR183 (0.52) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL2903272 | 0.91 | GPR183 (0.52) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL2902256 | 0.91 | GPR183 (0.52) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL2904845 | 0.91 | GPR183 (0.52) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL2902254 | 0.91 | GPR183 (0.52) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL2896228 | 0.91 | GPR183 (0.52) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL2903270 | 0.91 | GPR183 (0.52) | GPR183NPC1RAB9ATDP1CCR2 | |
| SCHEMBL2904311 | 0.91 | GPR183 (0.48) | GPR183ITGB2ICAM1ITGALNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010506-B1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-04 | — | — | EP | disclosed |