Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 19/20 | 0.74 |
| ▸ | AXL | P30530 | 2/20 | 0.58 |
| ▸ | MET | P08581 | 1/20 | 0.58 |
| ▸ | KDR | P35968 | 2/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.55 |
| ▸ | LCK | P06239 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.55 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | RET | P07949 | 1/20 | 0.55 |
| ▸ | FER | P16591 | 1/20 | 0.55 |
| ▸ | FLT1 | P17948 | 1/20 | 0.55 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | AKT2 | P31751 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30335951 | 1.00 | FLT3 (0.74) | FLT3AXLMETKDRPLK4 | |
| SCHEMBL28972505 | 0.91 | FLT3 (0.72) | FLT3AXLMET | |
| SCHEMBL30336593 | 0.91 | FLT3 (0.72) | FLT3AXLMET | |
| SCHEMBL30336053 | 0.91 | FLT3 (0.72) | FLT3AXLMET | |
| SCHEMBL28459591 | 0.91 | FLT3 (0.72) | FLT3AXLMET | |
| SCHEMBL28972374 | 0.91 | FLT3 (0.72) | FLT3AXLMET | |
| SCHEMBL30336210 | 0.91 | FLT3 (0.72) | FLT3AXLMET | |
| SCHEMBL30336351 | 0.90 | FLT3 (0.71) | FLT3AXLMETKDR | |
| SCHEMBL28972355 | 0.90 | FLT3 (0.71) | FLT3AXLMETKDR | |
| SCHEMBL30336362 | 0.88 | FLT3 (0.70) | FLT3AXLMETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111646995-B | 4-amino-pyrimidoazenitrogen heterocycle-phenylurea derivative and preparation method and application thereof | 四川大学 | 2023-03-21 | — | — | CN | disclosed |