SCHEMBL28973176

SCHEMBL28973176

CC1(C)C(=O)N(c2ccc(C#N)c(C(F)(F)F)c2)C(=S)N1[C@H]1CC[C@H](CCCBr)CC1

nearest known ligand 0.59

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AR P10275 17/20 0.59
HDAC1 Q13547 4/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28973179 1.00 AR (0.59) ARHDAC1
SCHEMBL28973188 0.97 AR (0.58) ARHDAC1
SCHEMBL28973192 0.97 AR (0.58) ARHDAC1
SCHEMBL28973225 0.96 AR (0.54) ARHDAC1
SCHEMBL25888419 0.91 AR (0.59) ARHDAC1
SCHEMBL28973178 0.91 AR (0.59) ARHDAC1
SCHEMBL28973197 0.91 AR (0.59) ARHDAC1
SCHEMBL28973195 0.91 AR (0.59) ARHDAC1
SCHEMBL28973134 0.88 AR (0.55) ARHDAC1
SCHEMBL28973135 0.88 AR (0.51) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115968293-A Cereblon binding compounds, compositions thereof, and methods of use thereof for treatment 新基公司 2023-04-14 CN disclosed
CN-115955979-A Cereblan binding compounds, compositions thereof, and methods for treatment thereof 新基公司 2023-04-11 CN disclosed
CN-115835866-A Cereblon binding compounds, compositions thereof, and methods of use thereof for treatment 新基公司 2023-03-21 CN disclosed