SCHEMBL28974597

SCHEMBL28974597

Nc1ccc(/C=C/c2ccc3c(c2)C(=O)c2ccccc2C3=O)cc1

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.63
ALDH1A1 P00352 2/20 0.63
RAB9A P51151 2/20 0.63
SMN1; SMN2 Q16637 2/20 0.63
TP53 P04637 1/20 0.63
CYP3A4 P08684 1/20 0.63
TSHR P16473 1/20 0.63
MAPK1 P28482 1/20 0.63
TDP1 Q9NUW8 1/20 0.63
PTPRC P08575 2/20 0.56
MEN1 O00255 1/20 0.56
APAF1 O14727 1/20 0.56
TDP2 O95551 1/20 0.56
NSD2 O96028 1/20 0.56
LMNA P02545 1/20 0.56
PLA2G1B P04054 1/20 0.56
POLB P06746 1/20 0.56
CTSL P07711 1/20 0.56
HPGD P15428 1/20 0.56
ALOX12 P18054 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28974598 1.00 NPC1 (0.63) NPC1ALDH1A1RAB9ASMN1; SMN2TP53
SCHEMBL18880862 0.94 CYP19A1 (0.57) NPC1ALDH1A1RAB9ASMN1; SMN2TP53
SCHEMBL28974650 0.87 MAOB (0.57) NPC1ALDH1A1RAB9ASMN1; SMN2TP53
SCHEMBL28974613 0.87 MAOB (0.57) NPC1ALDH1A1RAB9ASMN1; SMN2TP53
SCHEMBL28974560 0.86 CYP19A1 (0.59) NPC1ALDH1A1RAB9ASMN1; SMN2TP53
SCHEMBL28974558 0.86 CYP19A1 (0.59) NPC1ALDH1A1RAB9ASMN1; SMN2TP53
SCHEMBL30282677 0.86 CYP19A1 (0.59) NPC1ALDH1A1RAB9ASMN1; SMN2TP53
SCHEMBL13866099 0.85 NPC1 (0.48) NPC1ALDH1A1RAB9ASMN1; SMN2TP53
SCHEMBL28974616 0.82 ELANE (0.63) NPC1ALDH1A1RAB9ASMN1; SMN2TP53
SCHEMBL28974617 0.82 ELANE (0.63) NPC1ALDH1A1RAB9ASMN1; SMN2TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115703704-A (E) -2-styryl-9, 10-anthraquinone compound and application thereof 辽宁中健医药科技有限公司 2023-02-17 CN claimed
CN-115703704-A (E) -2-styryl-9, 10-anthraquinone compound and application thereof 辽宁中健医药科技有限公司 2023-02-17 CN disclosed