SCHEMBL28975147

SCHEMBL28975147

NCCNC(=O)c1ccc(COC(N)=S)cc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SPHK2 Q9NRA0 2/20 0.55
CYP1A2 P05177 2/20 0.54
TSHR P16473 1/20 0.54
NFKB1 P19838 1/20 0.54
MAOB P27338 1/20 0.54
MEN1 O00255 1/20 0.53
BLM P54132 1/20 0.53
PMP22 Q01453 1/20 0.53
KMT2A Q03164 1/20 0.53
TERT O14746 2/20 0.46
BRD4 O60885 2/20 0.44
F2 P00734 1/20 0.44
PLG P00747 1/20 0.44
PRSS1 P07477 1/20 0.44
PRSS2 P07478 1/20 0.44
PRSS3 P35030 1/20 0.44
TPSAB1 Q15661 1/20 0.44
TPSD1 Q9BZJ3 1/20 0.44
TPSG1 Q9NRR2 1/20 0.44
TOP2A P11388 2/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21742487 0.80 SPHK2 (0.59) SPHK2CYP1A2TSHRNFKB1MAOB
SCHEMBL3861146 0.79 MAOB (0.81) SPHK2CYP1A2TSHRNFKB1MAOB
SCHEMBL23254636 0.77 CYP1A2 (0.68) SPHK2CYP1A2TSHRNFKB1MAOB
SCHEMBL28830270 0.76 CYP1A2 (0.70) SPHK2CYP1A2TSHRNFKB1MAOB
SCHEMBL12141627 0.74 TSHR (0.64) SPHK2CYP1A2TSHRNFKB1MAOB
Hydrochloric Acid SCHEMBL32665514 0.74 BLM (0.71) SPHK2CYP1A2TSHRNFKB1MAOB
SCHEMBL748869 0.72 SPHK2 (0.81) SPHK2NFKB1MAOBMEN1KMT2A
SCHEMBL12913509 0.72 MAOB (0.70) SPHK2CYP1A2TSHRNFKB1MAOB
SCHEMBL11619588 0.72 TSHR (0.70) SPHK2CYP1A2TSHRNFKB1MAOB
Acetic Acid SCHEMBL9744237 0.71 CYP1A2 (0.58) SPHK2CYP1A2TSHRNFKB1MAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115867648-A Extension of chemical substrates for genetic code reprogramming to include long chain carbons and cyclic amino acids 西北大学 2023-03-28 CN disclosed