SCHEMBL28980481

SCHEMBL28980481

[c]1ccc(-c2cccc(OC3CCC3)n2)cc1

nearest known ligand 0.51

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 3/20 0.51
SLC6A4 P31645 3/20 0.51
KCNH2 Q12809 3/20 0.51
FFAR4 Q5NUL3 9/20 0.49
PIM1 P11309 5/20 0.41
PIM3 Q86V86 4/20 0.41
PIM2 Q9P1W9 4/20 0.41
BRD4 O60885 1/20 0.40
BTK Q06187 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19510682 0.82 FFAR4 (0.52) SLC6A2SLC6A4KCNH2FFAR4PIM1
SCHEMBL16334650 0.77 FFAR4 (0.55) SLC6A2SLC6A4KCNH2FFAR4PIM1
SCHEMBL2155077 0.74 BTK (0.45) SLC6A2SLC6A4KCNH2BTK
SCHEMBL16334974 0.74 FFAR4 (0.58) SLC6A2SLC6A4KCNH2FFAR4PIM1
SCHEMBL30967160 0.73 SLC6A2 (0.51) SLC6A2SLC6A4KCNH2FFAR4PIM1
SCHEMBL2330337 0.72 MEN1 (0.59)
SCHEMBL19511308 0.71 FFAR4 (0.72) SLC6A2SLC6A4KCNH2FFAR4PIM1
SCHEMBL30350593 0.71 FFAR4 (0.72) SLC6A2SLC6A4KCNH2FFAR4PIM1
SCHEMBL29582903 0.71 FFAR4 (0.69) FFAR4
SCHEMBL23967053 0.70 FFAR4 (0.40) SLC6A2SLC6A4KCNH2FFAR4PIM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-107567443-B Biaryl derivatives as GPR120 agonists 株式会社LG化学 2023-04-28 CN disclosed
CN-115925679-A Biaryl derivatives as GPR120 agonists 株式会社LG化学 2023-04-07 CN disclosed