Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Tyrosine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.47 |
| ▸ | ANPEP | P15144 | 1/20 | 0.44 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.44 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.44 |
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 3/20 | 0.42 |
| ▸ | KISS1R | Q969F8 | 4/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | ACE | P12821 | 1/20 | 0.40 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL27245950 | 0.95 | SLC7A5 (0.52) | SLC7A5ANPEPRNPEPDNPEPALPI | |
| Tyrosine SCHEMBL29061147 | 0.89 | SLC7A5 (0.42) | SLC7A5ANPEPRNPEPDNPEPALPI | |
| Tyrosine SCHEMBL10722796 | 0.88 | SLC7A5 (0.49) | SLC7A5ALPIPKMPTGS1XIAP | |
| Tyrosine SCHEMBL27245949 | 0.87 | SLC7A5 (0.61) | SLC7A5ANPEPALPIPKMPTGS1 | |
| Tyrosine SCHEMBL26978806 | 0.87 | SLC7A5 (0.61) | SLC7A5ANPEPRNPEPDNPEPALPI | |
| Dl-Phenylalanine SCHEMBL21410030 | 0.87 | SLC7A5 (0.56) | SLC7A5ANPEPRNPEPDNPEPALPI | |
| Tyrosine SCHEMBL28469095 | 0.86 | SLC7A5 (0.63) | SLC7A5ANPEPRNPEPDNPEPALPI | |
| Tyrosine SCHEMBL1764507 | 0.86 | SLC7A5 (0.63) | SLC7A5ANPEPRNPEPDNPEPALPI | |
| Tyrosine SCHEMBL27515946 | 0.86 | SLC7A5 (0.63) | SLC7A5ANPEPRNPEPDNPEPALPI | |
| Phenylalanine SCHEMBL3490090 | 0.85 | SLC7A5 (0.54) | SLC7A5ANPEPRNPEPDNPEPALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115960032-A | Aryloxy propanol amine beta-adrenaline receptor ligand with beta-arrestin biased agonistic activity and application thereof | 复旦大学 | 2023-04-14 | — | — | CN | disclosed |