SCHEMBL28986340

SCHEMBL28986340

COC(=O)CCC1(C)N=c2ccccc2=N1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.41
LMNA P02545 3/20 0.41
HSD17B10 Q99714 2/20 0.41
MAPT P10636 1/20 0.41
HTT P42858 1/20 0.41
KMT2A Q03164 1/20 0.41
KDM4E B2RXH2 2/20 0.40
TSHR P16473 2/20 0.40
CYP11B1 P15538 1/20 0.39
CYP11B2 P19099 1/20 0.39
AKT1 P31749 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.38
CNR1 P21554 1/20 0.37
CNR2 P34972 1/20 0.37
POLB P06746 1/20 0.37
HPGD P15428 1/20 0.37
ALOX15 P16050 1/20 0.37
MAPK1 P28482 1/20 0.37
RXFP1 Q9HBX9 1/20 0.37
CA12 O43570 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14361737 0.70 KDM1A (0.32) ALDH1A1LMNAHSD17B10MAPTKMT2A
SCHEMBL28986338 0.70 EGFR (0.42) ALDH1A1LMNAHSD17B10MAPTHTT
SCHEMBL28478377 0.70 MAPT (0.46) ALDH1A1LMNAHSD17B10MAPTHTT
SCHEMBL29441935 0.68 APEX1 (0.64) ALDH1A1LMNAHSD17B10MAPTHTT
SCHEMBL15691551 0.68 MAPT (0.47) ALDH1A1LMNAHSD17B10MAPTHTT
SCHEMBL29407802 0.68 APEX1 (0.64) ALDH1A1LMNAHSD17B10MAPTHTT
SCHEMBL7627154 0.68 APEX1 (0.64) ALDH1A1LMNAHSD17B10MAPTHTT
SCHEMBL29407803 0.68 APEX1 (0.64) ALDH1A1LMNAHSD17B10MAPTHTT
SCHEMBL4364129 0.67 HPGD (0.36) ALDH1A1LMNAHSD17B10HTTKMT2A
SCHEMBL17051238 0.67 PDK2 (0.44) ALDH1A1LMNAHSD17B10MAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115992192-A Method for synthesizing benzimidazole Michael addition derivative in continuous flow reactor 浙江工业大学 2023-04-21 CN disclosed