Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL30378600 | 1.00 | TDP1 (0.37) | TDP1MEN1THRBRECQLBLM | |
| Bromide SCHEMBL28991378 | 0.94 | TDP1 (0.37) | TDP1MEN1THRBRECQLBLM | |
| Bromide SCHEMBL30379370 | 0.94 | TDP1 (0.37) | TDP1MEN1THRBRECQLBLM | |
| Acetic Acid SCHEMBL30379172 | 0.90 | MEN1 (0.40) | TDP1MEN1THRBRECQLBLM | |
| Bromide SCHEMBL19878336 | 0.87 | MEN1 (0.51) | TDP1MEN1THRBRECQLBLM | |
| Acetic Acid SCHEMBL28991738 | 0.84 | MEN1 (0.40) | TDP1MEN1THRBRECQLBLM | |
| Bromide SCHEMBL19878453 | 0.81 | TDP1 (0.51) | TDP1MEN1THRBRECQLBLM | |
| SCHEMBL19878292 | 0.81 | MEN1 (0.46) | TDP1MEN1THRBRECQLBLM | |
| Acetic Acid SCHEMBL19878290 | 0.78 | MEN1 (0.52) | TDP1MEN1THRBRECQLBLM | |
| Acetic Acid SCHEMBL30378926 | 0.78 | MEN1 (0.52) | TDP1MEN1THRBRECQLBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109690317-B | Compositions and methods for measuring ion channel activity in cells | 生命科技股份有限公司 | 2023-05-02 | — | — | CN | disclosed |