Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 5/20 | 0.65 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.45 |
| ▸ | FYN | P06241 | 8/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.42 |
| ▸ | CDK9 | P50750 | 2/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 2/20 | 0.42 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.40 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905619 | 0.85 | KCNH2 (0.47) | MKNK1KCNH2FYNDYRK3CCNT1 | |
| SCHEMBL2906009 | 0.82 | FYN (0.51) | MKNK1KCNH2FYNDYRK3CCNT1 | |
| SCHEMBL17437976 | 0.82 | TYK2 (0.54) | MKNK1KCNH2FYNDYRK3CCNT1 | |
| SCHEMBL3033429 | 0.79 | MKNK1 (1.00) | MKNK1KCNH2FYN | |
| SCHEMBL3036704 | 0.79 | MKNK1 (0.77) | MKNK1KCNH2FYNDYRK3CCNT1 | |
| SCHEMBL1202745 | 0.77 | MKNK1 (0.56) | MKNK1KCNH2FYNDYRK3CCNT1 | |
| SCHEMBL21571847 | 0.77 | TYK2 (0.49) | MKNK1KCNH2FYNDYRK3CCNT1 | |
| SCHEMBL1202282 | 0.76 | MKNK1 (0.49) | MKNK1FYN | |
| SCHEMBL3031885 | 0.76 | MKNK1 (1.00) | MKNK1KCNH2FYNDYRK3CCNT1 | |
| SCHEMBL1202742 | 0.74 | MKNK1 (0.53) | MKNK1FYNDYRK3CCNT1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217601-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | Centro Nacional de Investigaciones Oncológicas (CNIO) (ES) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009060197-A1 | IMIDAZOPYRIDAZINES FOR USE AS PROTEIN KINASE INHIBITORS | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2009-05-14 | — | — | WO | disclosed |