Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 20/20 | 0.78 |
| ▸ | CIT | O14578 | 3/20 | 0.78 |
| ▸ | GAK | O14976 | 3/20 | 0.78 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.78 |
| ▸ | BMP2K | Q9NSY1 | 3/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.78 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.78 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.78 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.78 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.77 |
| ▸ | GSK3A | P49840 | 1/20 | 0.77 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.69 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.69 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.69 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.69 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.66 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.66 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28992899 | 1.00 | AAK1 (0.78) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL19025596 | 0.88 | AAK1 (1.00) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL30292388 | 0.88 | AAK1 (1.00) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL17143712 | 0.88 | AAK1 (1.00) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL19026356 | 0.87 | AAK1 (1.00) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL30292361 | 0.87 | AAK1 (1.00) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL17155505 | 0.87 | AAK1 (1.00) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL19025499 | 0.85 | AAK1 (1.00) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL17143799 | 0.85 | AAK1 (1.00) | AAK1CITGAKMKNK1BMP2K | |
| SCHEMBL30292383 | 0.85 | AAK1 (1.00) | AAK1CITGAKMKNK1BMP2K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023051749-A1 | AAK1 INHIBITOR AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2023-04-06 | — | — | WO | disclosed |
| CN-115872927-A | AAK1 inhibitors and uses thereof | 武汉人福创新药物研发中心有限公司 | 2023-03-31 | — | — | CN | disclosed |