SCHEMBL28993116

SCHEMBL28993116

O=C(O)C(Cl)(C(=O)c1ccccc1)c1ccc2ccccc2c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.42
KMT2A Q03164 4/20 0.42
TDP1 Q9NUW8 3/20 0.42
PTPN1 P18031 3/20 0.42
MAPT P10636 2/20 0.42
CES1 P23141 2/20 0.42
CES2 O00748 1/20 0.42
KAT6A Q92794 1/20 0.39
CYP1A2 P05177 1/20 0.39
KIF11 P52732 1/20 0.39
SLC13A5 Q86YT5 1/20 0.38
ALDH1A1 P00352 2/20 0.38
SMN1; SMN2 Q16637 2/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
MRGPRX4 Q96LA9 1/20 0.38
KDM4E B2RXH2 1/20 0.37
EGFR P00533 1/20 0.37
TP53 P04637 1/20 0.37
CYP3A4 P08684 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28993126 0.81 CYP1A2 (0.54) TDP1MAPTCES1CES2CYP1A2
SCHEMBL28993105 0.77 NPC1 (0.44) MEN1KMT2AMAPTCES1CYP1A2
SCHEMBL16147513 0.77 PTPN1 (0.53) MEN1KMT2ATDP1PTPN1MAPT
SCHEMBL28993094 0.76 CES1 (0.53) MEN1KMT2ATDP1MAPTCES1
SCHEMBL7861321 0.73 PTPN1 (0.47) MEN1KMT2ATDP1PTPN1MAPT
SCHEMBL29941124 0.73 PTPN1 (0.47) MEN1KMT2ATDP1PTPN1MAPT
SCHEMBL29226433 0.73 PTPN1 (0.47) MEN1KMT2ATDP1PTPN1MAPT
SCHEMBL4678770 0.70 PTPN1 (0.49) KMT2APTPN1MAPTCES1CES2
SCHEMBL9719820 0.70 PTPN1 (0.49) MEN1KMT2ATDP1PTPN1MAPT
SCHEMBL11587470 0.69 PTPN1 (0.50) TDP1PTPN1CES1CES2CYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116023202-A Synthetic method of alpha-chlorarone derivative 西南大学 2023-04-28 CN disclosed