Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Di(Hydroxyethyl)Ether. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.77 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | ODC1 | P11926 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Di(Hydroxyethyl)Ether SCHEMBL11310542 | 1.00 | TSHR (0.77) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Tetraethylene Glycol SCHEMBL28612085 | 0.96 | MEN1 (0.79) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL28235433 | 0.96 | MEN1 (0.79) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Di(Hydroxyethyl)Ether SCHEMBL9679975 | 0.96 | TSHR (0.71) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL503911 | 0.93 | TSHR (0.67) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Triethylene Glycol SCHEMBL28758058 | 0.93 | MEN1 (0.73) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL18700 | 0.93 | — | — | |
| SCHEMBL16329522 | 0.90 | MEN1 (0.69) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL313703 | 0.90 | MEN1 (0.69) | TSHRMAPK1MEN1KMT2AALDH1A1 | |
| Ethylene Glycol SCHEMBL22204609 | 0.90 | TSHR (0.62) | TSHRMAPK1MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117659340-A | Bio-based waterborne polyurethane for microfiber leather and preparation method and application thereof | 浙江梅盛新材料有限公司 | 2024-03-08 | — | — | CN | claimed |
| CN-116023628-A | Bio-based silicon-containing polyurethane, preparation method thereof and microfiber leather | 广州海豚新材料有限公司 | 2023-04-28 | — | — | CN | claimed |
| CN-117659340-A | Bio-based waterborne polyurethane for microfiber leather and preparation method and application thereof | 浙江梅盛新材料有限公司 | 2024-03-08 | — | — | CN | disclosed |
| CN-116023628-B | Bio-based silicon-containing polyurethane, preparation method thereof and microfiber leather | 广州海豚新材料有限公司 | 2023-09-12 | — | — | CN | disclosed |
| CN-116023628-A | Bio-based silicon-containing polyurethane, preparation method thereof and microfiber leather | 广州海豚新材料有限公司 | 2023-04-28 | — | — | CN | disclosed |