Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 2/20 | 0.54 |
| ▸ | APP | P05067 | 1/20 | 0.54 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.52 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.52 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | FDPS | P14324 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
| ▸ | TYR | P14679 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL289951 | 1.00 | TTR (0.54) | TTRAPPSIRT2SIRT1PTPN1 | |
| SCHEMBL17683319 | 1.00 | TTR (0.54) | TTRAPPSIRT2SIRT1PTPN1 | |
| SCHEMBL69618 | 0.88 | TTR (0.66) | TTRAPPSIRT2SIRT1PTPN1 | |
| SCHEMBL14299070 | 0.86 | TTR (0.60) | TTRAPPFDPSCA12CA1 | |
| SCHEMBL10745530 | 0.83 | APP (0.47) | TTRAPPSIRT2SIRT1PTPN1 | |
| SCHEMBL10745545 | 0.83 | APP (0.47) | TTRAPPSIRT2SIRT1PTPN1 | |
| SCHEMBL10745536 | 0.83 | APP (0.47) | TTRAPPSIRT2SIRT1PTPN1 | |
| SCHEMBL10745504 | 0.83 | APP (0.47) | TTRAPPSIRT2SIRT1PTPN1 | |
| SCHEMBL2280674 | 0.82 | TTR (0.58) | TTRAPPSIRT2SIRT1PTPN1 | |
| SCHEMBL1279909 | 0.82 | KDM4E (0.60) | TTRAPPSIRT1PTPN1CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102438975-B | Substituted aromatic and its medicinal usage | PROMETIC BIOSCIENCES INC. (CA) | 2015-12-16 | — | — | CN | disclosed |
| EP-2427416-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | ProMetic BioSciences Inc. (CA) | 2012-03-14 | — | — | EP | disclosed |
| WO-2010127440-A1 | SUBSTITUTED AROMATIC COMPOUNDS AND PHARMACEUTICAL USES THEREOF | PROMETIC BIOSCIENCES INC. (CA) | 2010-11-11 | — | — | WO | disclosed |