SCHEMBL28995484

SCHEMBL28995484

Cn1nc(N2CCC(=O)NC2=O)c2cc(F)c(C3=CCN(C(=O)O)CC3(F)F)cc21

nearest known ligand 0.47

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 4/20 0.47
▸ CRBN Q96SW2 4/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23538259 0.89 DDB1 (0.43) DDB1CRBN
SCHEMBL29535442 0.89 DDB1 (0.43) DDB1CRBN
SCHEMBL23538715 0.85 DDB1 (0.55) DDB1CRBN
SCHEMBL31612881 0.81 DDB1 (0.51) DDB1CRBN
SCHEMBL23538304 0.77 DDB1 (0.53) DDB1CRBN
SCHEMBL28995503 0.76 DDB1 (0.52) DDB1CRBN
SCHEMBL23539015 0.76 DDB1 (0.47) DDB1CRBN
SCHEMBL31548330 0.76 DDB1 (0.47) DDB1CRBN
SCHEMBL24881548 0.76 DDB1 (0.45) DDB1CRBN
SCHEMBL23539369 0.74 CRBN (0.50) DDB1CRBN

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114901277-A Isoindolinone and indazole compounds for EGFR degradation C4医药公司 2022-08-12 — — CN disclosed
Send feedback