SCHEMBL2900490

SCHEMBL2900490

Cc1sc2c(c1C)C(c1ccc(NC(=O)CCc3ccccc3)cc1)=N[C@@H](CC(=O)O)c1nnc(C)n1-2

nearest known ligand 0.87

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 18/20 0.87
BRD2 P25440 4/20 0.66
BRD3 Q15059 2/20 0.66
HDAC1 Q13547 3/20 0.65
BRDT Q58F21 2/20 0.64
HDAC3 O15379 1/20 0.63
HDAC4 P56524 1/20 0.63
HDAC7 Q8WUI4 1/20 0.63
HDAC2 Q92769 1/20 0.63
HDAC10 Q969S8 1/20 0.63
HDAC11 Q96DB2 1/20 0.63
HDAC8 Q9BY41 1/20 0.63
HDAC6 Q9UBN7 1/20 0.63
HDAC9 Q9UKV0 1/20 0.63
HDAC5 Q9UQL6 1/20 0.63
NAMPT P43490 2/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23321207 0.94 BRD4 (0.80) BRD4BRD2BRD3HDAC1BRDT
SCHEMBL13028892 0.93 BRD4 (1.00) BRD4BRD2BRD3HDAC1BRDT
SCHEMBL3197761 0.93 BRD4 (0.78) BRD4BRD2BRD3HDAC1BRDT
SCHEMBL3208282 0.92 BRD4 (0.74) BRD4BRD2BRD3HDAC1BRDT
SCHEMBL3212487 0.92 BRD4 (0.81) BRD4BRD2BRD3HDAC1BRDT
SCHEMBL3201391 0.89 BRD4 (0.73) BRD4BRD2BRD3BRDT
SCHEMBL24630369 0.87 BRD4 (0.74) BRD4BRD2BRD3HDAC1BRDT
SCHEMBL3200903 0.87 BRD4 (0.71) BRD4BRD2BRD3BRDT
SCHEMBL24630213 0.87 BRD4 (0.74) BRD4BRD2BRD3HDAC1BRDT
SCHEMBL3208242 0.87 BRD4 (0.72) BRD4BRD2BRD3HDAC1BRDT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 63 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1887008-B1 THIENOTRIAZOLODIAZEPINE COMPOUND AND A MEDICINAL USE THEREOF MITSUBISHI TANABE PHARMA CORP (JP) 2021-04-21 EP claimed
US-20170157141-A1 METHOD OF TREATING LEUKEMIA USING PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS ONCOETHIX GMBH (CH) 2017-06-08 US claimed
EP-3154549-A1 METHOD OF TREATING NON-SMALL CELL LUNG CANCER AND/OR SMALL CELL LUNG CANCER USING THIENOTRIAZOLODIAZEPINE COMPOUNDS Oncoethix GmbH (CH) 2017-04-19 EP claimed
US-20160375032-A1 METHOD OF TREATING NON-SMALL-CELL LUNG CANCER USING PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS ONCOETHIX GMBH (CH) 2016-12-29 US claimed
US-20160158245-A1 PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS ONCOETHIX SA (CH) 2016-06-09 US claimed
US-20160158246-A1 METHOD OF TREATING DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) USING A BET-BROMODOMAIN INHIBITOR ONCOETHIX GMBH (CH) 2016-06-09 US claimed
WO-2015189814-A1 METHOD OF TREATING NON-SMALL CELL LUNG CANCER AND/OR SMALL CELL LUNG CANCER USING THIENOTRIAZOLODIAZEPINE COMPOUNDS ONCOETHIX GMBH (CH) 2015-12-17 WO claimed
US-9125915-B2 Antitumor agent MITSUBISHI TANABE PHARMA CORPORATION (JP) 2015-09-08 US claimed
WO-2015018520-A1 A BET-BRD INHIBITOR REPRESENTS A NOVEL AGENT FOR ALK POSITIVE ANAPLASTIC LARGE CELL LYMPHOMA ONCOETHIX SA (CH) 2015-02-12 WO claimed
US-20140107107-A1 PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS ONCOETHIX GMBH (CH) 2014-04-17 US claimed
US-8476260-B2 Antitumor agent MITSUBISHI TANABE PHARMA CORPORATION (JP) 2013-07-02 US claimed
US-20100286127-A1 ANTITUMOR AGENT MITSUBISHI TANABE PHARMA CORPORATION (JP) 2010-11-11 US claimed
EP-2239264-A1 ANTITUMOR AGENT Mitsubishi Tanabe Pharma Corporation (JP) 2010-10-13 EP claimed
US-20100041643-A1 THIENOTRIAZOLODIAZEPINE COMPOUND AND MEDICINAL USE THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2010-02-18 US claimed
EP-1887008-A1 THIENOTRIAZOLODIAZEPINE COMPOUND AND A MEDICINAL USE THEREOF Mitsubishi Tanabe Pharma Corporation (JP) 2008-02-13 EP claimed
EP-1887008-B1 THIENOTRIAZOLODIAZEPINE COMPOUND AND A MEDICINAL USE THEREOF MITSUBISHI TANABE PHARMA CORP (JP) 2021-04-21 EP disclosed
US-10813939-B2 Bromodomain inhibitor as adjuvant in cancer immunotherapy H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) 2020-10-27 US disclosed
EP-2239264-A1 ANTITUMOR AGENT Mitsubishi Tanabe Pharma Corporation (JP) 2010-10-13 EP disclosed
US-20100041643-A1 THIENOTRIAZOLODIAZEPINE COMPOUND AND MEDICINAL USE THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2010-02-18 US disclosed
EP-1887008-A1 THIENOTRIAZOLODIAZEPINE COMPOUND AND A MEDICINAL USE THEREOF Mitsubishi Tanabe Pharma Corporation (JP) 2008-02-13 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160158246-A1 METHOD OF TREATING DIFFUSE LARGE B-CELL LYMPHOMA (DLBCL) USING A BET-BROMODOMAIN INHIBITOR BRD4, BRD7, BCL6 BRD4 1/4885BRD2 10/4885BRD3 5/4885
US-20170157141-A1 METHOD OF TREATING LEUKEMIA USING PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS CCR10, HRH4, H1-10 BRD4 22/4885BRD2 128/4885BRD3 119/4885
US-10813939-B2 Bromodomain inhibitor as adjuvant in cancer immunotherapy BRDT, BRD4, BRD1 BRD4 2/4885BRD2 4/4885BRD3 5/4885
US-20140107107-A1 PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS HRH4, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HTR3D BRD4 97/4885BRD2 121/4885BRD3 80/4885
US-20100286127-A1 ANTITUMOR AGENT BRDT, HDAC1, BRPF3 BRD4 4/4885BRD2 8/4885BRD3 6/4885
US-20160375032-A1 METHOD OF TREATING NON-SMALL-CELL LUNG CANCER USING PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HRH4, CCR10 BRD4 20/4885BRD2 137/4885BRD3 128/4885
US-20100041643-A1 THIENOTRIAZOLODIAZEPINE COMPOUND AND MEDICINAL USE THEREOF ICOS, CD4, CD2 BRD4 265/4885BRD2 318/4885BRD3 342/4885
US-20160158245-A1 PHARMACEUTICAL FORMULATION CONTAINING THIENOTRIAZOLODIAZEPINE COMPOUNDS ABL1, BCR, FLT3 BRD4 16/4885BRD2 62/4885BRD3 24/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.