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SCHEMBL29005406

SCHEMBL29005406

CC(=O)N(c1cccc(Cl)c1)c1cc(NC(=O)Cc2ccc(F)cc2Cl)ccn1.CC(=O)N(c1cccc(Cl)c1)c1cc(NC(=O)Cc2ccccc2Cl)ccn1

nearest known ligand 0.63

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
▸ P2RX4 Q99571 6/20 0.63
▸ KCNJ5 P48544 4/20 0.52
▸ KCNJ3 P48549 4/20 0.52
▸ ANO1 Q5XXA6 8/20 0.47
▸ RORA P35398 1/20 0.43
▸ NR2E1 Q9Y466 1/20 0.43
▸ KCNJ6 P48051 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24173483 0.96 P2RX4 (0.58) P2RX4KCNJ5KCNJ3ANO1
SCHEMBL29005403 0.95 P2RX4 (0.65) P2RX4KCNJ5KCNJ3ANO1RORA
SCHEMBL30285879 0.94 P2RX4 (0.70) P2RX4KCNJ5KCNJ3ANO1RORA
SCHEMBL26186552 0.94 P2RX4 (0.70) P2RX4KCNJ5KCNJ3ANO1RORA
SCHEMBL26186501 0.92 P2RX4 (0.68) P2RX4KCNJ5KCNJ3ANO1RORA
SCHEMBL30285601 0.92 P2RX4 (0.68) P2RX4KCNJ5KCNJ3ANO1RORA
SCHEMBL29005405 0.91 P2RX4 (0.53) P2RX4KCNJ5KCNJ3ANO1RORA
SCHEMBL29005387 0.91 P2RX4 (0.67) P2RX4KCNJ5KCNJ3ANO1RORA
SCHEMBL30285854 0.91 P2RX4 (0.59) P2RX4ANO1
SCHEMBL26186502 0.91 P2RX4 (0.59) P2RX4ANO1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115996911-A Substituted N-phenylacetamides having P2X4 receptor antagonistic activity 拜耳公司 2023-04-21 — — CN claimed
CN-115989218-A Use of N-phenylacetamides having P2X4 receptor antagonistic activity for the treatment of certain eye diseases 拜耳公司 2023-04-18 — — CN claimed