Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 18/20 | 0.89 |
| ▸ | AKT1 | P31749 | 2/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2907762 | 0.94 | MTOR (1.00) | MTORAKT1 | |
| SCHEMBL4177877 | 0.84 | AKT1 (1.00) | MTORAKT1 | |
| SCHEMBL2908112 | 0.83 | MTOR (1.00) | MTORAKT1 | |
| SCHEMBL2901002 | 0.83 | MTOR (1.00) | MTORAKT1KCNH2 | |
| SCHEMBL2907878 | 0.82 | KCNH2 (0.67) | MTORKCNH2 | |
| SCHEMBL2907141 | 0.82 | MTOR (1.00) | MTORAKT1 | |
| SCHEMBL2905752 | 0.82 | MTOR (1.00) | MTOR | |
| SCHEMBL14114023 | 0.82 | MTOR (0.90) | MTORAKT1 | |
| SCHEMBL22449835 | 0.82 | MTOR (0.90) | MTORKCNH2 | |
| SCHEMBL2909940 | 0.81 | MTOR (1.00) | MTORAKT1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2217234-A2 | COMBINATIONS OF MEK INHIBITORS WITH MTOR INHIBITORS | AstraZeneca AB (SE) | 2010-08-18 | — | — | EP | disclosed |
| WO-2009050506-A2 | COMBINATION 059 | ASTRAZENECA AB (SE) | 2009-04-23 | — | — | WO | disclosed |