Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | ITK | Q08881 | 14/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | CDK7 | P50613 | 1/20 | 0.40 |
| ▸ | CLK2 | P49760 | 2/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | FER | P16591 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | MARK3 | P27448 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1622112 | 0.80 | ITK (0.55) | CYP19A1ITKCHEK1CDK7CLK2 | |
| SCHEMBL17422783 | 0.71 | CYP19A1 (0.71) | CYP19A1CHEK1FLT3CSNK2A1 | |
| SCHEMBL141689 | 0.69 | ITK (0.73) | ITKCHEK1CDK2 | |
| SCHEMBL15741187 | 0.67 | MAPK1 (0.49) | CHEK1CDK7CLK2DYRK1APRKD3 | |
| SCHEMBL17422896 | 0.66 | CYP19A1 (0.59) | CYP19A1CHEK1FLT3CSNK2A1 | |
| SCHEMBL17433444 | 0.65 | CYP19A1 (0.62) | CYP19A1ITKCHEK1DYRK1AFLT3 | |
| SCHEMBL6479098 | 0.64 | CYP19A1 (0.53) | CYP19A1ITKFLT3CSNK2A1 | |
| SCHEMBL15741280 | 0.64 | TNKS2 (0.44) | PDPK1 | |
| SCHEMBL17433446 | 0.64 | CYP19A1 (0.61) | CYP19A1ITKCHEK1FLT3CSNK2A1 | |
| SCHEMBL17422937 | 0.64 | CYP19A1 (0.71) | CYP19A1ITKCHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1682553-B1 | THIENOPYRAZOLES | AVENTIS PHARMA INC (US) | 2010-05-19 | — | — | EP | disclosed |