Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 15/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 13/20 | 0.37 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.33 |
| ▸ | GSPT1 | P15170 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | NPY2R | P49146 | 1/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25335434 | 0.86 | CRBN (0.37) | CRBNDDB1GSPT1ESR1NPY2R | |
| SCHEMBL25035469 | 0.83 | CRBN (0.39) | CRBNDDB1GSPT1POLBNPY2R | |
| SCHEMBL25031444 | 0.83 | DDB1 (0.45) | CRBNDDB1ESR1NPY2RKDM1A | |
| SCHEMBL30981022 | 0.83 | DDB1 (0.45) | CRBNDDB1ESR1NPY2RKDM1A | |
| SCHEMBL25253102 | 0.81 | NPY2R (0.39) | CRBNDDB1GSPT1NPY2RKDM1A | |
| SCHEMBL30479015 | 0.81 | CRBN (0.38) | CRBNDDB1IKZF3GSPT1POLB | |
| SCHEMBL25822081 | 0.81 | DDB1 (0.45) | CRBNDDB1NPY2RKDM1A | |
| SCHEMBL30981345 | 0.80 | CRBN (0.44) | CRBNDDB1GSPT1POLB | |
| SCHEMBL24670689 | 0.78 | CRBN (0.44) | CRBNDDB1GSPT1POLBESR1 | |
| SCHEMBL30135729 | 0.78 | CRBN (0.44) | CRBNDDB1GSPT1POLBESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116261458-B | PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2024-05-24 | — | — | CN | disclosed |
| CN-116261458-A | Novel PLK1 degradation inducing compounds | 厄普特拉株式会社 | 2023-06-13 | — | — | CN | disclosed |