Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYK2 | P29597 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | IKBKE | Q14164 | 2/20 | 0.39 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.36 |
| ▸ | PRKCI | P41743 | 1/20 | 0.36 |
| ▸ | ITK | Q08881 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL114359 | 0.77 | TYK2 (0.65) | TYK2RAB9ANPC1IKBKETBK1 | |
| SCHEMBL3368022 | 0.70 | TYK2 (0.70) | TYK2RAB9ANPC1KMT2AHTT | |
| SCHEMBL1161155 | 0.69 | TYK2 (0.69) | TYK2RAB9ANPC1KMT2A | |
| SCHEMBL15504912 | 0.68 | ABL1 (0.62) | TYK2ABL1NPC1KMT2A | |
| SCHEMBL21938137 | 0.68 | TYK2 (0.68) | TYK2RAB9ANPC1KMT2AHTT | |
| Hydrochloric Acid SCHEMBL2591261 | 0.68 | TYK2 (0.68) | TYK2RAB9ANPC1KMT2A | |
| SCHEMBL3635868 | 0.67 | TYK2 (1.00) | TYK2RAB9ANPC1KMT2ARXFP1 | |
| SCHEMBL7285113 | 0.66 | TYK2 (0.64) | TYK2RAB9ANPC1KMT2AHTT | |
| SCHEMBL21938139 | 0.66 | TYK2 (0.60) | TYK2RAB9ANPC1KMT2A | |
| SCHEMBL10063177 | 0.63 | ITK (0.62) | IKBKETBK1PRKCIITK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116096708-A | Derivatives of 2-oxo-N- (4- (pyrimidin-4-yloxy/thio) phenyl) -1, 2-dihydropyridine-3-carboxamide as protein kinase inhibitors for therapy | 澳升医药公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-116096708-A | Derivatives of 2-oxo-N- (4- (pyrimidin-4-yloxy/thio) phenyl) -1, 2-dihydropyridine-3-carboxamide as protein kinase inhibitors for therapy | 澳升医药公司 | 2023-05-09 | — | — | CN | disclosed |
| CN-116096708-A | Derivatives of 2-oxo-N- (4- (pyrimidin-4-yloxy/thio) phenyl) -1, 2-dihydropyridine-3-carboxamide as protein kinase inhibitors for therapy | 澳升医药公司 | 2023-05-09 | — | — | CN | disclosed |