Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | OTUD7B | Q6GQQ9 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30552358 | 0.83 | CRBN (0.56) | CRBNDDB1SCN5ASCN9AOTUD7B | |
| SCHEMBL30552354 | 0.83 | CRBN (0.56) | CRBNDDB1SCN5ASCN9AOTUD7B | |
| SCHEMBL25215318 | 0.78 | CRBN (0.41) | CRBNDDB1SCN5ASCN9ACYP3A4 | |
| SCHEMBL17350152 | 0.75 | PDE7A (0.42) | CRBNMAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL19225163 | 0.72 | PDE7A (0.47) | CRBNMAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL10758073 | 0.71 | PDE7A (0.54) | MAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL30552386 | 0.70 | BACE1 (0.47) | CRBNMAPK1KMT2AMEN1ALDH1A1 | |
| SCHEMBL25386692 | 0.69 | NR1H2 (0.48) | MAPK1 | |
| SCHEMBL17524916 | 0.69 | SCN9A (0.43) | CRBNDDB1SCN9AMAPK1KMT2A | |
| SCHEMBL6618655 | 0.68 | CRBN (0.61) | CRBNDDB1SCN5ASCN9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116157398-A | 2- (4- ((5- (benzo [ b ] thiophen-3-yl) -1H-tetrazol-1-yl) methyl) phenyl) -5- (difluoromethyl) -1,3, 4-oxadiazole derivatives and similar compounds as selective inhibitors of histone deacetylase 6 (HDAC 6) for the treatment of, for example, peripheral neuropathy | 意大发马克股份公司 | 2023-05-23 | — | — | CN | disclosed |