Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 6/20 | 0.51 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5579256 | 0.86 | GAA (0.66) | GAATHRBMAPTALOX15HSD17B10 | |
| SCHEMBL29397014 | 0.85 | GAA (0.56) | GAATHRBMAPTALOX15HSD17B10 | |
| SCHEMBL22963745 | 0.85 | GAA (0.56) | GAATHRBMAPTALOX15HSD17B10 | |
| SCHEMBL22963778 | 0.79 | GAA (0.53) | GAATHRBMAPTALOX15HSD17B10 | |
| SCHEMBL29396335 | 0.79 | GAA (0.53) | GAATHRBMAPTALOX15HSD17B10 | |
| SCHEMBL21606298 | 0.79 | MEN1 (0.60) | GAATHRBMAPTALOX15HSD17B10 | |
| SCHEMBL30908507 | 0.79 | MEN1 (0.60) | GAATHRBMAPTALOX15HSD17B10 | |
| SCHEMBL22963688 | 0.76 | MAPT (0.53) | GAATHRBMAPTALOX15HSD17B10 | |
| SCHEMBL22912782 | 0.75 | MAPT (0.55) | GAATHRBMAPTALOX15HSD17B10 | |
| SCHEMBL29394281 | 0.75 | MAPT (0.55) | GAATHRBMAPTALOX15HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116348115-A | Combination of antibody-drug conjugate and PARP1 selective inhibitor | 阿斯利康(英国)有限公司 | 2023-06-27 | — | — | CN | disclosed |