Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Imiquimod. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 known ✓ | Q9NYK1 | 16/20 | 0.93 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.93 |
| ▸ | LMNA | P02545 | 1/20 | 0.93 |
| ▸ | POLB | P06746 | 1/20 | 0.93 |
| ▸ | HRH2 | P25021 | 1/20 | 0.93 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.93 |
| ▸ | HTR2A | P28223 | 1/20 | 0.93 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.93 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.93 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.93 |
| ▸ | HTR2B | P41595 | 1/20 | 0.93 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.93 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Imiquimod SCHEMBL1301796 | 0.97 | TLR7 (0.97) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL570774 | 0.96 | TLR7 (1.00) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL26136 | 0.96 | TLR7 (1.00) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL29357252 | 0.96 | TLR7 (1.00) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL17962753 | 0.95 | TLR7 (0.97) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL5262205 | 0.93 | TLR7 (0.88) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL3191041 | 0.92 | TLR7 (0.86) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL3415170 | 0.91 | TLR7 (0.84) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL5260618 | 0.90 | TLR7 (0.82) | TLR7PDE4DLMNAPOLBHRH2 | |
| Imiquimod SCHEMBL3188551 | 0.90 | TLR7 (0.82) | TLR7PDE4DLMNAPOLBHRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116212016-A | Immune adjuvant-loaded phycocyanin nano-system and preparation method and application thereof | 江苏大学 | 2023-06-06 | — | — | CN | disclosed |