Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 7/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 10/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2903092 | 0.78 | PDE4A (0.38) | PDE4ASLC6A4SLC6A2SLC6A3PDE4D | |
| SCHEMBL2903523 | 0.73 | PDE4A (0.47) | PDE4ASLC6A4SLC6A2SLC6A3PDE4D | |
| Hydrochloric Acid SCHEMBL2908528 | 0.73 | PDE4A (0.47) | PDE4ASLC6A4SLC6A2SLC6A3PDE4D | |
| Hydrochloric Acid SCHEMBL2902642 | 0.73 | PDE4D (0.39) | PDE4ASLC6A4SLC6A2SLC6A3PDE4D | |
| SCHEMBL2903522 | 0.69 | PDE4A (0.39) | PDE4ASLC6A4SLC6A2SLC6A3PDE4D | |
| Hydrochloric Acid SCHEMBL2908525 | 0.68 | PDE4A (0.38) | PDE4ASLC6A4SLC6A2SLC6A3PDE4D | |
| SCHEMBL2902564 | 0.68 | SLC6A2 (0.41) | PDE4ASLC6A4SLC6A2SLC6A3PDE4D | |
| SCHEMBL2901823 | 0.67 | PDE4A (0.41) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL2905266 | 0.67 | PDE4A (0.44) | PDE4APDE4DPDE4BPDE4C | |
| SCHEMBL5648505 | 0.67 | SLC6A4 (0.46) | SLC6A4SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1692109-B1 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS | MEMORY PHARM CORP (US) | 2010-08-18 | — | — | EP | disclosed |
| EP-1692109-A2 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS | Memory Pharmaceuticals Corporation (US) | 2006-08-23 | — | — | EP | disclosed |
| US-20050222207-A1 | Phosphodiesterase 4 inhibitors, including N-substituted diarylamine analogs | MEMORY PHARMACEUTICAL CORPORATION | 2005-10-06 | — | — | US | disclosed |
| WO-2005061458-A2 | PHOSPHODIESTERASE 4 INHIBITORS, INCLUDING N-SUBSTITUTED DIARYLAMINE ANALOGS | MEMORY PHARMACEUTICALS CORPORATION (US) | 2005-07-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222207-A1 | Phosphodiesterase 4 inhibitors, including N-substituted diarylamine analogs | PDE4A, PDE4B, PDE3B | PDE4A 1/4885SLC6A4 595/4885SLC6A2 1346/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.