Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR183 | P32249 | 7/20 | 0.48 |
| ▸ | CCR2 | P41597 | 8/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | SLC2A1 | P11166 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2901948 | 0.95 | GPR183 (0.46) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL2897386 | 0.95 | GPR183 (0.49) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL2897389 | 0.95 | GPR183 (0.49) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL2904862 | 0.93 | GPR183 (0.46) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL2899681 | 0.93 | GPR183 (0.46) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL2899682 | 0.93 | GPR183 (0.46) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL2904254 | 0.90 | GPR183 (0.45) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL2897160 | 0.90 | GPR183 (0.45) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL2898826 | 0.90 | GPR183 (0.45) | GPR183CCR2NPC1RAB9ATDP1 | |
| SCHEMBL2901878 | 0.90 | GPR183 (0.45) | GPR183CCR2NPC1RAB9ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2010506-B1 | DIAZEPAN DERIVATIVES MODULATORS OF CHEMOKINE RECEPTORS | HOFFMANN LA ROCHE (CH) | 2010-08-04 | — | — | EP | disclosed |