Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 15/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 10/20 | 0.57 |
| ▸ | AKT2 | P31751 | 10/20 | 0.57 |
| ▸ | AKT3 | Q9Y243 | 10/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29036005 | 1.00 | AKT1 (0.58) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL29157947 | 0.94 | AKT1 (0.57) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL30012817 | 0.94 | AKT1 (0.57) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL29157946 | 0.94 | AKT1 (0.57) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL390393 | 0.88 | AKT1 (0.70) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL390394 | 0.88 | AKT1 (0.70) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL31374403 | 0.84 | JAK3 (0.58) | AKT1ROCK2AKT2AKT3JAK3 | |
| SCHEMBL390884 | 0.84 | JAK3 (0.58) | AKT1ROCK2AKT2AKT3JAK3 | |
| SCHEMBL391355 | 0.82 | AKT1 (0.71) | AKT1ROCK2AKT2AKT3KCNH2 | |
| SCHEMBL10156733 | 0.82 | AKT1 (0.64) | AKT1ROCK2AKT2AKT3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115232130-A | APN and AKT double-target-point inhibitor and preparation method and application thereof | 山东大学 | 2022-10-25 | — | — | CN | disclosed |